Registration Number
0215U006296,
0115U000251
, R & D reports
Title
Determine the role of T-helper 17 type in the formation of systemic inflammation in patients with the chronic obstructive lung disease
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Head
Rekalova Elena Myhaylovna,
Registration Date
05-01-2016
Organization
SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine"
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Object - the peripheral blood of 65 patients with thy chronic obstructive pulmonary desease (COPD) in the acute stage, 24 patients with COPD in remission; 11 patients with chronic bronchitis (CB) in remission, 10 healthy persons. Aim - to find out the role of T-helper type 17 in the pathogenesis of chronic obstructive pulmonary diseases and their participation in the developmant of systemic inflammation in the patients with COPD. Methods - clinical, immunological, statistical. Llymphopenia, decrease namber of pan-T lyphocyte with depression of T-cells and functional activity, increased number of blood neutrophils, the increaseg serum level of C-reactiv protein were characteristic for the patients with exacerbation of COPD withe cardiovascular desease. In remission phase the patients with COPD had increased number of blood natural killers and B-lymphocytes, the increased level of IL17A,, TNF and C-reactiv protein, compared with the patients with CB. Monotsitopeniya and decreased of serum TNF concentration were characteristic in the patients with remission of CB. This indicate on the absence of immunological inflammatory signs in the patients with CB. The technology for identification of the concomitant cardiovascular diseases in patients with COPD was developed. Sphere of application - immunology, pulmonology
Product Description
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Кадан Людмила Павлівна
Казачук Ірина Анатоліівна
Кулик Микола Іванович
Матвієнко Юлія Олександрівна
Панасюкова Оксана Романівна
Панащук Ігор Олексійович
Рекалова Олена Михайлівна
Сінгаєвський Мирослав Богданович
Чернушенко Катерина Федорівна
Ясирь Світлана Григорівна
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2020-04-02
