Registration Number
0215U008308,
0115U002969
, R & D reports
Title
Study of enzymocytochemical and immunocytological features of hematopoietic progenitor cells at the different types of hemoblastosis
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Head
Gluzman Danylo Fishelevych, Доктор медичних наук
Registration Date
24-12-2015
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
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Cell immunophenotype of different forms of B-cell non-Hodgkin lymphomas in leukemization phase was studied by the improved procedure of immunocytochemical reactions directly in the native smears of blood marrow. The rare cases of B-cell non-Hodgkin lymphomas were scrutinized wherein the cells representing the small lymphocytes morphologically and cytochemically lacked CD5 and/or CD23 expression. In such cases, the diagnostic panel should be supplemented with anti-cyclin D monoclonal antibody giving positive reaction in mantle cell lymphoma and negative in marginal zone lymphoma. In rare cases of CD5– mantle cell lymphoma, the use of anti-CD43 monoclonal antibody has been proved advantageous from diagnostic point. CD43 expression in addition to cyclin D1 is regarded as pathognomic of mantle cell lymphoma allowing for verifying one of the rarest forms of lymphoid neoplasms.
Product Description
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Іванівська Тетяна Степанівна
Глузман Данило Фішелєвич
Кірієнок Галина Валентинівна
Коваль Стелла Володимирівна
Поліщук Альона Станіславівна
Полудненко Людмила Юріївна
Скляренко Ліілія Михайлівна
Українська Наталія Іванівна
Швидка Марина Сергіївна
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2020-04-02
