Registration Number
0215U008316,
0115U004759
, R & D reports
Title
Fluorescence visualization and SERS diagnostics of modern biologically active medications with nanoparticles
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Head
Strelchuk Viktor Vasylyovych, Доктор фізико-математичних наук
Registration Date
24-12-2015
Organization
Institute of Semiconductor Physics of National Academy of Sciences of Ukrain
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he optimization of the properties of advanced bioactive nanocomposite therapeutic drugs with antitumor effect based on of the molecules of oksirezveratrol, konium, doxorubicin, polysaccharides, bacterial reaction centers, NADH and carbon nanostructures at radiation exposure was carried out. The electron-molecular conformational transformations of nanocomplexes and the ability to improve the efficiency of antineoplastic drugs was studied. The analysis of the mechanisms of antitumor action of drugs with carbon and metal nanostructures on the properties of the solvent and dose radiation exposure was performed. The investigation of the efficiency of prepared SERS substrates with metal nanoparticles in the dependence of technological parameters of colloidal synthesis and laser ablation were performed. The interconnection between the efficiency of analytic response, optical, structural and morphological properties of nanostructured SERS substrates and their functionalization methods was found. The practical testing of the prepared SERS substrates was carried out for the following biological objects: synthesized malignant tumor cell of the breast adenocarcinoma and ovarian carcinoma. The substantial spectral differences between the benign and malignant tumors, in particular, the changes in the frequency and intensity within the spectral range of proteins, nucleic acids and lipids were found.
Product Description
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Бойко М.І.
Коломис О.Ф.
Куліш М.П.
Ніколенко А.С.
Насєка В.М.
Насєка Ю.М.
Стубров Ю.Ю.
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2020-04-02
