Updated: 2025-12-16
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0216U000017, 0113U000285 , R & D reports
To investigate an influence of xenogenic transplantation of native and transfinite mesenhymal stem cells on flow of experimental allergic encefaphalomyelitis
Дослідити вплив ксеногенної трансплантації нативних та трансфікованих мезенхімальних стовбурових клітин на перебіг експериментального алергічного енцефаломієліту
Tsymbaluk Vitaliy Ivanovich,
14-01-2016
State institution ''Institute of Neurosurgery n.acad. AP. Romodanov NAMS of Ukraine''
Object of study - inflammative and degenerative disease of central nervous system (CNS) in animals with autoimmune component - experimental encephalomyelitis (EAE). Subject of study - experimental animals (rats) with induced EAE. Purpose of study - to improve the outcomes of treatment of EAE in rats by utilization of transplantation of human's native Wharton's jelly-derived mesenchymal stem cells and transfected IL-10 mesenchymal stem cells. Methods: 1. experimental study (study of biological properties and proliferative potential of human's Wharton's jelly-derived mesenchymal stem cells in vitro, EAE modeling, treatment with MSC and IL-10, objectifying of EAE severity and studying of dynamics of behavorial reactions; 2. immunological study (peripheral blood study, evaluation of spontaneous cytotoxicity of mononuclear cells of the spleen, evaluation of mythohondrial dehydrogenase activity in monuclear cells of the spleen by MTT-test, evaluation of levels of circulating immune complexes in blood serum, identification of anti- myelin basic protein (MBP) IgE in rats blood serum by reaction of mast cell degranulation test; 3. morphological study (light- and electronic microscopy); 4. Statistic analysis (Mann-Whitney U-test, t-test and others. The protocol of human's Wharton's jelly-derived mesenchymal stem cells obtaining was developed, phenotypic changes and proliferative potential of MSC during their cultivation was studied. Experimental study of pathogenetic chains of inflammative and degenerative changes of CNS with autoimmune component in rats was conducted, influence of transplantation of human's native Wharton's jelly-derived mesenchymal stem cells and transfected IL-10 mesenchymal stem cells, in order to form new immune status and production of IL-10 in experimental rats, was studied. The influence of new method of treatment on behavorial reactions in rats during the experiment, processes of axons remyelination and reparative changes in CNS tissues were studied. Area of application - neurosurgery.
Єгорова Діана Михайлівна
Бельська Людмила Миколаївна
Васлович Вікторія Вікторівна
Величко Ольга Миколаївна
Вербовська Світлана Анатоліївна
Гнедкова Ірина Володимирівна
Дерябіна Олена Григорівна
Дунаєвська Людмила Олександрівна
Касяненко Юрій Анатолійович
Ковальчук Марія Володимирівна
Лісяний Микола Іванович
Маркова Ольга Володимирівна
Пічкур Леонід Дмитрович
Пічкур Олександр Леонідович
Похоленко Яніна Олександрівна
Руденко Валентина Андріївна
Семенова Віра Михайлівна
Стайно Лариса Петрівна
Топорова Олена Карнеліївна
Фофонова Катерина Василівна
2020-04-02
Updated: 2025-12-16
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