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Information × Registration Number 0216U002308, 0113U004155 , R & D reports Title Genetic markers of recurrent pregnancy losses. popup.stage_title Head Zastavna Danuta, Registration Date 15-02-2016 Organization Scientific-research institute of Hereditary pathology popup.description2 The complex cytogenetic, immunogenetic and molecular genetic studies of early regular reproductive losses in human (recurrent pregnancy loss) were performed for the first time. Results of studies conducted on models interphase nuclei derived from uncultivated and short time cultivated chorionic villi, DNA and RNA extracted from white blood cells of peripheral blood of marriage and chorionic villi samples of spontaneously eliminated in embryos showed besides to the karyotype of the fetus, high homology of couple for DRB1 + DQA1 + DQB1 - loci genes of major histocompatibility complex class II, informative genetic markers of early embryo losses in humans are: the homozygous genotype for the insertion allele polymorphism of insertion/deletion of 14 bp nonclassical HLA-G-gene of HLA-class systems in mother and/or fetus, loss of imprinting gene of insulin-like growth factor IGF-II in the fetus and the presence of genotype TT (pp) and AA (mm) of polymorphic locus c.454-397 T > C (PvuII) of ESR1 gene in marriage. Product Description popup.authors Віштак Наталія Валентинівна Гельнер Надія Володимирівна Гулеюк Наталія Любомирівна Заставна Данута Володимирівна Макух Галина Василівна Сосніна Катерина Олександрівна Тенета Мар'яна Михайлівна Терпиляк Ореста Ігорівна Тиркус Марта Ярославівна Ткач Ірина Романівна Третяк Богдан Іренеєвич Чорна Лілія Богданівна popup.nrat_date 2020-04-02 Close