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Information × Registration Number 0216U002942, 0115U002969 , R & D reports Title Study of enzymocytochemical and immunocytological features of hematopoietic progenitor cells at the different types of hemoblastosis popup.stage_title Head Gluzman Danylo Fishelevych, Доктор медичних наук Registration Date 28-12-2016 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Based on the study of enzymocytochemical features and immunophenotypic profile of the malignant lymphoid cells, the basic criteria for diagnosing more aggressive forms of B-cell chronic lymphocytic leukemia (B-CLL) have been defined. In contrast with the typical B-CLL (CD19+CD20+CD5+CD23+CD43+), mixed cell B-CLL variant with the increased prolymphocyte count in the peripheral blood and decreased CD23 and CD5 expression (less than in 50% of cells) was delineated characterized by the rapid disease progression and highly unfavorable prognosis necessitating the intensive protocol chemotherapy initiated promptly after diagnosing. Product Description popup.authors Іванівська Тетяна Степанівна Глузман Данило Фішелєвич Кірієнок Галина Валентинівна Коваль Стелла Володимирівна Петрусь Наталія Олександрівна Поліщук Альона Станіславівна Скляренко Ліілія Михайлівна Українська Наталія Іванівна Швидка Марина Сергіївна popup.nrat_date 2020-04-02 Close