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Information × Registration Number 0216U003067, 0114U000716 , R & D reports Title Preparation of stable tumor cell lines expressing phenotypic and molecular features of cancer stem cells (CSCs), to develop and monitor the effectiveness of new anticancer drugs: evaluation of mTOR/S6K-dependent signaling pathways popup.stage_title Head Filonenko Valeriy Viktorovitch, Доктор біологічних наук Registration Date 12-01-2016 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 It was demonstrated that Ruk1 expression induced cell resistance inhibitor of mTORC1 rapamycin. This in turn may be related to the fact that the specific activation (phosphorylation) of key substrates of mTOR/C1 and mTOR/C2 - protein 4 EBP, S6K1 and Akt and their subcellular localization in cells with stable expression Ruk1 differs significantly from the original cells. A monoclonal antibody to components of mTOR/C1 and mTOR/C2 complexes proteins Rictor and Raptor have been generated and subcellular localization of signaling complexes in model cancer stem cells was analyzed Product Description popup.authors Кіямова Рамзія Галямівна Маланчук Оксана Миколаївна Овчаренко Галина Вікторівна popup.nrat_date 2020-04-02 Close