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Information × Registration Number 0216U003412, 0113U000152 , R & D reports Title To work out the methods of prophylactics and treatment of pregnancy, delivery and postnatal period disorders in women with large interval between births popup.stage_title Head Tumanova L.E., Registration Date 27-01-2016 Organization State organization "Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine" popup.description2 The frequency of births to women with large interhenetychnym interval increased with 1.98 in 1987 to 10.7% in 2007. In these women is a high relative number extragenital pathology, especially diseases of the cardiovascular system to 30%, obesity 12 % varicose veins - 16%, diseases of the gastrointestinal tract - 34%, and others. More than 50% of pregnant women had abortions before the second birth. It was determined that a large interhenetychnyy interval associated with a high frequency of pregnancy complications (impending spontaneous miscarriage - 52%, premature birth - 12%, preeclampsia - 36%, anemia - 16%, fetal distress, fetal growth retardation - 9%). Proved that pregnant women with great interhenetychnym interval are a group with a high level of anxiety markedly unstable psycho-emotional state, and reduced quality of life. Revealed that a large interhenetychnyy interval in pregnant women is accompanied by a significant decrease in the concentration of hormones feto-placental complex, representing the state of placental insufficiency in the majority of women surveyed increase in stress-related hormones (cortisol and serotonin). For the group of women with large intervals interhenetychnym inherent increase of interleukin-8 in both the first and second trimester, corresponding threat prevalence of abortion in women. Confirmed the protective role of GM-CSF. Pregnant women with a large interval formed interhenetychnym partial failure of local cervical immune system, which is implemented lack of synthesis of secretory immunoglobulin A and accompanied by the appearance of cervical mucus every fifth pregnant immunoglobulin M. Most women with large intervals are interhenetychnym genital infections caused by facultative anaerobic bacteria. The peculiarity of the identified pathogens is their frequent association. Women who give birth after 30 years of often manifested Staphilococcus epidermidis 7 (35%), Staphilococcus faecalis 6 (30%), Candida Albicans 6 (30%). Found elevated levels of precancerous cervical pathology in pregnant women with great interhenetychnym intervals and in the age of pregnant women compared to young pregnant women in which the interval between births is small - 3-5 years. A small part difference precancerous lesions of the cervix: 22.5% - women in group 1 and 22.2% - women in group 2, said that with increasing age the probability samoeliminatsiyi papillomavirus is reduced accordingly increased risk development of precancer and cervical cancer. Based on these data developed a set of preventive measures for women with large rummaged between births. Applications developed complex promoted improvement of pregnancy, childbirth and the condition of the fetus, which is associated with positive effects on indicators of hormonal function and blood circulation and morphology of placenta abruption. The changes in utero-placental and fetal-placental blood flow in women with large interhenetychnym interval. Product Description popup.authors Єщенко О. Іщенко Г. Деменіна Н. Донской Б. Зосіменко Л. Коломієць О. Мілєвський О. Осипчук Д. Подольський В. Сорокін О. Стамболі Л. Травнікова Н. Хомінська З. Чернишов В. Шевченко Л. popup.nrat_date 2020-04-02 Close