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Information × Registration Number 0216U003546, 0113U002316 , R & D reports Title Molecular and cerebral mechanisms of cogniive disorders as a result of premature aging. popup.stage_title Head Bazyka D.; Loganovsky K., Registration Date 01-02-2016 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of research: cognitive function and peripheral blood leukocytes of 326 Chornobyl clean-up workers and 104 subjects exposed in utero and in early childhood as a result of the Chornobyl accident. Objective: to determine the molecular-biological and cerebral mechanisms of cognitive dysfunction as a result of Chornobyl exposure to low doses of ionizing radiation as a manifestation of human aging. Methods of research - clinical, immunological, molecular. Chornobyl clean-up workers after exposure to doses of 500 mSv exhibited more marked cognitive deficit compared to groups exposed to 500 mSv, non-exposed groups and exposed in utero. IQ disharmony was shown with lower verbal intelligence IQ compared to non-verbal. Mean relative telomere length in cleanup workers was decreased after 50 years (6.1%), after 70 years (11.7%). In the range of low doses decreased RTL associated with TERT2 overexpression and low expression of TERT were found. At doses above 250-500 mSv we demonstrate overexpression of TERF1, TERT genes and reduced of TERF2 gene expression, associated with cognitive impairment and dementia. Product Description popup.authors Ільєнко Ірина Миколаївна Антипчук Катерина Юріївна Бєляєв Олег Анатолійович Бєляєва Надія Володимирівна Бомко Марія Олександрівна Гресько М.В. Колосинська О.О. Крейніс Г.Ю. Кубашко Алла Володимирівна Куц К.В. Логановська Тетяна К Мазніченко Оксана Леонідівна Масюк С.В. Музалевська Катерина Дмитрівна Перчук І.В. Чепурний М.І. Чумак Станіслав Анатолійович Чупровська Наталія Юріївна popup.nrat_date 2020-04-02 Close