Registration Number
0216U003546,
0113U002316
, R & D reports
Title
Molecular and cerebral mechanisms of cogniive disorders as a result of premature aging.
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Head
Bazyka D.; Loganovsky K.,
Registration Date
01-02-2016
Organization
State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine "
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Object of research: cognitive function and peripheral blood leukocytes of 326 Chornobyl clean-up workers and 104 subjects exposed in utero and in early childhood as a result of the Chornobyl accident. Objective: to determine the molecular-biological and cerebral mechanisms of cognitive dysfunction as a result of Chornobyl exposure to low doses of ionizing radiation as a manifestation of human aging. Methods of research - clinical, immunological, molecular. Chornobyl clean-up workers after exposure to doses of 500 mSv exhibited more marked cognitive deficit compared to groups exposed to 500 mSv, non-exposed groups and exposed in utero. IQ disharmony was shown with lower verbal intelligence IQ compared to non-verbal. Mean relative telomere length in cleanup workers was decreased after 50 years (6.1%), after 70 years (11.7%). In the range of low doses decreased RTL associated with TERT2 overexpression and low expression of TERT were found. At doses above 250-500 mSv we demonstrate overexpression of TERF1, TERT genes and reduced of TERF2 gene expression, associated with cognitive impairment and dementia.
Product Description
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Ільєнко Ірина Миколаївна
Антипчук Катерина Юріївна
Бєляєв Олег Анатолійович
Бєляєва Надія Володимирівна
Бомко Марія Олександрівна
Гресько М.В.
Колосинська О.О.
Крейніс Г.Ю.
Кубашко Алла Володимирівна
Куц К.В.
Логановська Тетяна К
Мазніченко Оксана Леонідівна
Масюк С.В.
Музалевська Катерина Дмитрівна
Перчук І.В.
Чепурний М.І.
Чумак Станіслав Анатолійович
Чупровська Наталія Юріївна
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2020-04-02
