Registration Number
0216U005319,
0114U000057
, R & D reports
Title
To determine the prognostic role of angiogenesis synthesis as possible markers in evaluation of efficacy of chemoradiation therapy for non-small-cell lung cancer.
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Head
Starenkyi V.P., Mitryaeva N.A.,
Registration Date
07-07-2016
Organization
Grigor'ev Institut for Medical Radiology
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Object of research: efficiency of conformal radiation therapy at 30 patients, the VEGF level in blood serum at 64 patients and CYFRA 21-1 at 30 patients with non-small cells lung cancer (NSCLC) in dynamics of antineoplastic therapy. Target of research: is to define prognostic criteria of treatment control according to studying of an expression of an angiogenesis regulators as efficiency markers of chemoradiotherapy of non small cells lung cancer. Methods of research and equipment: clinical and insrtumental, immunoenzymometric, electron-microscopic, dosimetric, statistical; the immunoenzymometric analyzer AIP-01C, sliding microtome SM-2, the Universal dosimeter UNIDOS_E, the linear accelerator Clinac 600С. Theoretical and practical results: the efficiency of treatment on the objective response to conformal radiotherapy of non small cells lung cancer is proved (partial regression and stabilization - 83%, progression - 17%). The ratio between dynamic changes of levels of serumal VEGF, CYFRA 21-1 at conformal radiation therapy of NSCLC and the objective response to treatment is defined. The hyperexpression of VEGF is a prognostic marker of efficiency of radiation therapy of NSCLC. The ways of monitoring of complex treatment and efficiency of radiation therapy of non-small cell lung cancer are developed. Novelty: for the first time it is defined that the coefficient of a ratio of the VEGF levels before and after treatment correlates with objective response on conformal radiotherapy of non small cells lung cancer. Efficiency of implementation: forehanded choice of adequate treatment will allow to enlarge the delaying time to relapse and survivability and to reduce the period of stay of this category of patients in a hospital. Domain of usage: medical radiology and oncology.
Product Description
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Білозор Н.В.
Басилайшвілі С.Ю.
Волошина Н.М.
Гребіник Л.В.
Канцедал О.М.
Карвасарська В.В.
Кондрашова О.І.
Лукашова О.П.
Мітряєва Н.А.
Масленнікова О.Л.
Насонова А.М.
Панов О.В.
Потапова Т.І.
Пшишевська Л.А.
Синиченко О.В.
Спузяк Р.М.
Старенький В.П.
Тесленко І.М.
Ткаченко А.А.
Узлєнкова Н.Є.
Федоренко К.С.
Шевцов В.Г.
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2020-04-02
