Registration Number
0216U005571,
0115U003716
, R & D reports
Title
Plasmon sensing for high-sensitive diagnostics of ultra-small quantity of chemical matters and biomolecules..The second year of implementation
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Head
Strelchuk V. Dmitrenko O. Ivanov,
Registration Date
03-02-2016
Organization
Department for special training National academy of science of Ukraine at Kiev University
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As the result of the project implementation, the original method for preparation of the effective nanostructured SERS-enhancing surfaces with the functionalized metallic nanoparticles, rough surfaces and island-like films of metals of Au and Ag were proposed. The investigation of effectiveness of obtained SERS-substrates with metallic nanoparticles depend on the technical conditions of their preparation were performed. The parameters of the SERS-active substrates and experimental conditions of detection of extrasmall quantities of the chemical matters (Rhodamine 6G) and biological molecules (glucose, DNA, tumor cells) were optimized. The correlation between the effectiveness of the analytical response and the optical, structural and morphological properties of the nanostructured SERS-substrates and the methods of their functionalization were found. The differences in the vibrational spectra of the standard tumor cells and the cells, treated with the gold nanoparticles as the changes of the frequencies and the intensities of the different spectral regions (proteins, nuclear acids, lipids) were registered and analyzed.?
Product Description
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Бойко Микола Іванович
Дмитренко О.П.
Коломис Олександр Федорович,
Куліш Микола Полікарпович
Ніколенко Андрій Сергійович
Насєка Юрій Миколайович
Павленко Олена Леонідівна,
Романюк Артем Сергійович
Стрельчук В.В.
Стубров Юрій Юрійович
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2020-04-02
