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Information × Registration Number 0216U006004, 0115U004861 , R & D reports Title The development of methods for the synthesis of new chemical compounds - potential inhibitors of hepatitis C virus replykatsiyi popup.stage_title Head Moroz Yurij, Registration Date 13-01-2016 Organization Taras Shevchenko Kiev university popup.description2 106 synthesized compounds - nitrogen-containing tricyclic compounds that have been characterized and chromatographic purification methods of 1H NMR spectroscopy hromatomasspektrometriyi. Among these 43 compounds found effective inhibitors of RNA synthesis with an IC50 value of less than 10 microns. Revealed that the highest activity of RNA synthesis inhibition demonstrate arylamidy tricyclic heterocyclic compounds, while alkilamidy poorly and initial acid did not affect the level of RNA synthesis even in the initial concentration. Product Description popup.authors Бойко О.М. Желуденко М.В. Зозуля С.О. Кондратюк А.С. Мороз Ю.С. Наумчик В.С. Толмачов А.О. popup.nrat_date 2020-04-02 Close