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Information × Registration Number 0216U006714, 0115U002262 , R & D reports Title Explore epithelial-mesenchymal transition and its relationship with tumor cells expressing the marker proteins of epithelial stem cells in the progression of cancer of the oral cavity. popup.stage_title Head Sydorenko Mychail V., Registration Date 05-05-2016 Organization Department of Biotechnical Problems of Diagnostics, Institute of Problems of Cryobiology and Cryomedicine of NAS of Ukraine popup.description2 Abstract.Research report 24 pages , 2 table, 3 р., 17 source literature. One of the most common mechanisms of epithelial-mesenchymal transition is the suppression of expression of E-katgerin - a transmembrane protein that provides homotypic adhesion of epithelial tissues. Lack of E-katgerin leads to the release and translocation to the nucleus of its partner terminal beta-catenin, which activates the transcription of a gene-level cell proliferation and adhesion control. Objective was to study the expression of the proteins ?-catenin and E-katgerin in squamous cell carcinoma of the oral mucosa. The material of the study were samples of surgical specimens of 20 patients with squamous cell carcinoma of the oral mucosa. We used morphological, immunohistochemical and statistical methods. The study found that the positive expression as E-katgerin and ?-catenin, determined in all tumors studied. Revealed heterogeneity of the cell population by the expression and localization of adhesion protein E-katgerin and ?-catenin. It has been shown that tumors with high expression of nuclear beta.-catenin have low expression of E-katgerin and high proliferative activity associated with epithelial-mesenchymal transition. KEY WORDS: Squamous cell carcinoma of the oral cavity, epithelial-mesenchymal transition, marker proteins. Product Description popup.authors Вдовиченко Н.О. Лебєдєва Т.М. Першко Н.Ю. Сидоренко Михайло Васильвич Юрченко Наталя Петрівна popup.nrat_date 2020-04-02 Close