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Information × Registration Number 0216U007486, 0116U006538 , R & D reports Title Development of technology for production of recombinant analog of protein ASK1 (apoptosis signal-regulating kinase 1) and search for inhibitors of this enzyme as potential therapeutic agents popup.stage_title Head Volynets Galyna Petrivna, Registration Date 19-12-2016 Organization Institute of Molecular Biology and Genetics popup.description2 Producer strain of Escherichia coli, which produces protein kinase ASK1 was received and this enzyme in the preparative amounts was obtained. The virtual screening of compound collection toward ASK1 was performed and the values of free energy for formation of ASK1 complexes with inhibitors were calculated using umbrella sampling algorithm. Accordingly to the data of virtual screening, we have selected compounds for investigation of their inhibitory activity toward recombinant protein ASK1 and determined the functional activity of recombinant ASK1.5481 Product Description popup.authors Волинець Галина Петрівна Горбатюк Оксана Борисівна popup.nrat_date 2020-04-02 Close