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Information × Registration Number 0216U008332, 0114U001099 , R & D reports Title To determine the etiopathogenetic mechanisms of changes in the functional activity of the components of hemostasis in patients with hemophilia in the background comorbidity popup.stage_title Head Juschenko P.V., Registration Date 29-12-2016 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Investigated 370 patients with hemophilia and 60 practically healthy people. Research methods: clinical, biochemical, hematological, math. Created a comprehensive dynamic model of functioning of system of hemostasis in patients with hemophilia in the context of the comorbidities and pathogenically substantiated a new concept of substitution transfusion therapy. It is established that partial preservation of the hemostatic potential in patients with hemophilia can occur due to a decrease in the anticoagulant activity of blood plasma. Proven to reduce natural protection of exogenous, endogenous f VIII, von Willebrand factor from the influence of protein C. The presence of three main types of response to applied therapy of coagulation factors depending on comorbide condition of the patient (preficient, normal and deficient). It is proved that the presence of inflammatory processes articular apparatus significantly affects the activity prothrombinasogeneration due to additional consumption factors sitting blood in the area of inflammation. It is shown, that application of preparations of factor VIII reduces the level of average weight molecules and improves liver function. It is proved that with the developed model it is possible to predict the risk of bleeding, and specifying the mode of application of preparations of blood coagulation factors. The concept of a vicarious pathogenically grounded hemostatic therapy needs is the need for taking into account the different response to drugs of coagulation factors in comorbid conditions in patients with hemophilia on the basis of data of individual pharmacokinetics. Medicine and social effect. Medicine. Product Description popup.authors Авер'янов Є.В. Аношина М.Ю. Баронська Л.В. Бурнаєва С.В. Семеняка В.І. Старіков А.В. Яговдік М.В. popup.nrat_date 2020-04-02 Close