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Information × Registration Number 0216U009187, 0114U003515 , R & D reports Title Laccase - mediator oxidation systems popup.stage_title Head Shendrik Oleksandr Mykolayovych, Registration Date 03-01-2017 Organization Donetsk State University popup.description2 In the model system with laccase Trametes Versicolor performed a comprehensive systematic study of a wide range of compounds, modeling fragments of molecules of lignin, flavonoids and other polyphenolic compounds of natural origin. In particular, such substrates have been investigated as a veratryl alcohol, halogenated polyphenols and 7,8-dihydroxy-4-oxymethylcoumarin. Was studied the effect on the catalytic activity of laccase Trametes Versicolor nonspecific (pH and solvent composition) and specific (the structure of the substrate and the mediator) factors. That may be used in further practical laccase-oxidation systems for various purposes: processing of natural lignin plant raw material fractions, sewage, water contaminated halogenated phenols. Revealed the presence of a high activity 2,2'-azino-bis (3-etilbenzotiazolin-6-sulfonic) acid, N-hydroxyphthalimide, N-hydroxybenztriazole and 4-methoxy-N-hydroxyphthalimide as mediator towards veratric alcohol in a simplified model system of the oxidized form mediator-substrate. Was investigated the relation of the reactivity of the compounds with the structure of a number of new potentially biologically active dihydroxyphenylthiazoles in the reaction with the oxidized form of the laccase mediator cation-radical of 2,2'-azino-bis (3-etilbenzotiazolin-6-sulfonic) acid. It was shown that the reaction center, responsible for antiradical properties of dihydroxyphenylthiazoles in aqueous and aqueous-organic media is dihydroxyaryl portion of the molecule. Product Description popup.authors Бураков Іван Миколайович Душенко Олена Ігорівна Зосенко Ольга Олександрівна Лаховець Катерина Максимівна Лесишина Юлія Остапівна Мельниченко Василь Іванович Одарюк Вікторія Валентинівна Плешигер Тетяна Сергіївна Цяпало Олександр Степанович popup.nrat_date 2020-04-02 Close