Search academic texts

Registration Number

0216U009187, 0114U003515 , R & D reports

Title

Laccase - mediator oxidation systems

popup.stage_title

Head

Shendrik Oleksandr Mykolayovych,

Registration Date

03-01-2017

Organization

Donetsk State University

popup.description2

In the model system with laccase Trametes Versicolor performed a comprehensive systematic study of a wide range of compounds, modeling fragments of molecules of lignin, flavonoids and other polyphenolic compounds of natural origin. In particular, such substrates have been investigated as a veratryl alcohol, halogenated polyphenols and 7,8-dihydroxy-4-oxymethylcoumarin. Was studied the effect on the catalytic activity of laccase Trametes Versicolor nonspecific (pH and solvent composition) and specific (the structure of the substrate and the mediator) factors. That may be used in further practical laccase-oxidation systems for various purposes: processing of natural lignin plant raw material fractions, sewage, water contaminated halogenated phenols. Revealed the presence of a high activity 2,2'-azino-bis (3-etilbenzotiazolin-6-sulfonic) acid, N-hydroxyphthalimide, N-hydroxybenztriazole and 4-methoxy-N-hydroxyphthalimide as mediator towards veratric alcohol in a simplified model system of the oxidized form mediator-substrate. Was investigated the relation of the reactivity of the compounds with the structure of a number of new potentially biologically active dihydroxyphenylthiazoles in the reaction with the oxidized form of the laccase mediator cation-radical of 2,2'-azino-bis (3-etilbenzotiazolin-6-sulfonic) acid. It was shown that the reaction center, responsible for antiradical properties of dihydroxyphenylthiazoles in aqueous and aqueous-organic media is dihydroxyaryl portion of the molecule.

Product Description

popup.authors

Бураков Іван Миколайович
Душенко Олена Ігорівна
Зосенко Ольга Олександрівна
Лаховець Катерина Максимівна
Лесишина Юлія Остапівна
Мельниченко Василь Іванович
Одарюк Вікторія Валентинівна
Плешигер Тетяна Сергіївна
Цяпало Олександр Степанович

popup.nrat_date

2020-04-02