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Information × Registration Number 0217U000010, 0116U000185 , R & D reports Title To develop short-schemes for treatment of drug-resistant tuberculosis popup.stage_title Head Lytvynenko Nataliia Anatoliyvna, Registration Date 05-01-2017 Organization Institute of tuberculosis and pulmonology named by F. G. Yanovsky popup.description2 Object: 1279 patients with MDR TB. Aim: to determine the optimal chemotherapy regimens for patients with mono- and poly-resistence, RifTB, MDR and XDR TB depending on the number, amount of anti-TB drugs at the treatment regimen, the length of intensive and continuation phases of chemotherapy, which will increase the treatment efficasy and save public funds. Methods: clinical, radiological, laboratory, microbiological. The method of sequential therapy of linezolid, levofloxacin and PAS consisting of anti-TB chemotherapy when starting treatment until the termination of bacteria used these drugs intravenously, turning to them oral application to completion of chemotherapy, to improve the effectiveness of treatment by 16,7 % intensive phase, to reduce to 5 months by reducing the time bacterial for 42 days, the reduction of "cost-effectiveness" of 1,2 times and saving public money by reducing the stationary phase of treatment, against the same frequency of adverse iventes. The reasons of poor results at the time of completion of treatment, loss of efficiency is to outpatient (at the end of the intensive phase of effective treatment in patients with MDR was 67,0 % and at the end of continuation phase - only 21,0 %, 15,0 % of patients were lost to follow-up). The main reasons were: lack of the required number of outpatient TB drugs, lack of social support for patients, imperfect system of monitoring adverse reactions to anti-TB drugs. Sphere of application - phthisiology Product Description popup.authors Аврамчук Оксана Володимирівна Варицька Ганна Олександрівна Веселовський Леонід Вікторович Гранкіна Наталія Вячеславівна Грицова Наталія Анатоліївна Гульчук Наталія Михайлівна Давиденко Валентина Василівна Зайков Сергій Вікторович Кужко Михайло Михайлович Литвиненко Наталія Анатоліївна Пісковець Лариса Іванівна Погребна Марина Віталіївна Процик Любомир Миронович Рамзан Ніна Ігорівна Сенько Юлія Олександрівна Старічек Г. В. Чоботар Оксана Петрівна Щербакова Леся Вікторівна popup.nrat_date 2020-04-02 Close