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Information × Registration Number 0217U000014, 0116U000189 , R & D reports Title Develop technology treatment of bronchial asthma in children, depending on the pheno-genotypic characteristics of the organism popup.stage_title Head Rechkina Olena Oleksandrivna, Registration Date 05-01-2017 Organization Institute of tuberculosis and pulmonology named by F. G. Yanovsky popup.description2 Object: 136 children with bronchial asthma (BA). Aim - improving the efficiency of treatment of children with asthma, on the basis of new scientific evidence on the association of polymorphic variants of genes and the establishment of candidate genes that determine individual response to drugs are the basic treatment, the formation of pheno-genotypes of bronchial asthma in children and the development of the algorithm of differentiated selection schemes base therapy of pheno-genotypic differences. Methods - clinical, questionnaires, functional, immunological, molecular genetic, mathematics, statistics. It was found insufficient efficiency of standard schemes of basic therapy (BT) of asthma in most children. The level of asthma control was ineffective BT with inhalation glucocorticosteroid (IGCS) -monoterapy among 38.8% of children and IGCS with beta2-agonist at 31.3%, mainly of medium asthma. The effectiveness of standard BT schemes confirmed integral indices, indicators of adaptive immunity and the parameters of external respiratory function. Established controlled (low compliance, inadequate dose / ICS mode and technology inhalation, insufficient weight of a body child, sympathicotonic, hyperimmunoglobulinemia G) and uncontrolled (combination of deletion and heterozygous polymorphism gene glutathione-S-transferase or vascular tone AT2R1 gene with the gene of the enzyme N-acetyl-transferase type 2 NAT C41T in different hetero- and homozygous combinations) treatment failure factors. The absence of a unified mechanism for individual selection of treatment encourages to find ways of objective criteria of therapeutic tactics. Sphere of application - pediatry, pulmonology, allergology Product Description popup.authors Ільїнська Ірина Федорівна Дорошенкова Анна Сергіївна Копосова Ірина Вікторівна Костроміна Вікторія Павлівна Кравцова Оксана Миколаївна Мельник Катерина Олександрівна Петішкіна Валерія Миколаївна Промська Наталія Вікторівна Речкіна Олена Олександрівна Россоха З. І. Руденко Сегрій Миколайович Стриж Віра Олександрівна Ясир С. Г. popup.nrat_date 2020-04-02 Close