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Information × Registration Number 0217U000133, 0113U007711 , R & D reports Title Develop set of criteris for obijectification of mild and moderate traumatic brain injiury in acute, intermediate and long-term periods (clinical, neuroimaging and laboratory investigations) popup.stage_title Head Pedachenko E.G., Registration Date 20-01-2017 Organization Academician A.Romodanov Institute of neurosurgery AMSc of Ukraine popup.description2 Scientific report: 162 pp., 32 fig., 44 tab., 313 springs. Research object - easy and moderate TBI. Objective: To investigate the possibility of determining biomarkers in a light i objectification of medium brain injury. The steady increase in injuries with increasing weight determines TBI sustained interest of researchers to the problem of traumatic brain injury. Among traumatic brain injuries are most common mild (70% - 80%) and the average (10% - 12%) the severity of TBI. Neyrovizualizuyuchi diagnostic methods - computed tomography (CT) and magnetic resonance imaging modes T-1 and T-2 (MRI) have become routine for the present, left unresolved the question some verification tool easy and moderate traumatic brain injury . Particularly acute diagnostic reliability LCHMT appears during forensic and medical-labor examination since diagnosis at LCHMT mainly is based on clinical anamnesis. The investigation of patients with mild to moderate traumatic brain injury: clinical neurology, neurophysiological (qEEG, cognitive caused protentsialy) neyroimunolohichni (state subpopulations of lymphocytes (SD3,4,8,19,16) and their functional activity, to determine the functional activity of neutrophils in the NBT test, the level of autoantibodies to neyrobilkiv (MBP, S-100, NSE, total brain antigen), circulating immune complexes, determination of protein S-100V) neyrovizualizuyuchyy (CT, MRI, DTT). Determined large and small clinical risk factors for the selection of patients with a probability of detection of traumatic changes during the KT research. CT scan shows the presence of at least one large or two small factor factors. The maximum setting S100V protein <100 pg / mL 6 hours after the first injury predictor may be effective in identifying patients with LCHMT with normal CT scan, that patients with brain concussion or contusion of the soft tissues of the head. Implementation of the data in practice will reduce the number of CT studies with true negative result. This will reduce radiation exposure for the patient and the costs of the study. The study showed that neurophysiological methods of digital EEG cognitive and auditory evoked potentials (equipment) should be used in screening diagnosis of patients who have suffered a slight head injury; if significant deviations of parameters and EEG equipment is recommended to conduct neuropsychological testing using test Mosa scales, HADS, Shas. Based on the study of auditory P300 equipment in the dynamics of treatment nootropics patients undergoing lChMT revealed significant (p <0.05) improvement (normalization) indicators latency and amplitude of these complexes, fully consistent with the positive clinical effect, namely the restoration the normal processes of concentration and the amount of RAM. The study shows that DTT (fractional anisotropy parameters, average diffusion region of interest) and SPECT is an effective means of objectification LCHMT, including concussion of the brain. The paper offers advice on the need to further develop reference indicators FA and SD, the absolute values ??of MC in the brain in the areas of interest. For this purpose, developed physical and mathematical model of hemodynamic cerebral quantify the cerebral blood flow volume according scintigraphy with 99mTs -HMPAO. This will determine the parameters on numerical models for indirect angiography results and determine the effectiveness dilution volume of blood in the brain, according to single photon emission computed tomography calculate volumetric cerebral blood flow. Areas of application - neyrotravmatolohiya. Projected assumptions about the development of design. The results will help clarify the diagnosis, which is important not only for clinical practice, but also for forensic and medical-labor examination .; will provide the basic pathogenic mechanisms that determine or influence the course prohrediyentnist rehrediyentnist or TBI, monitor and adjust the effectiveness of the treatment process. KEYWORDS: light and moderate traumatic brain injury, biomarkers, neuroimaging, neurophysiological research Product Description popup.authors Андрєєв О.А. Бельська Л.М. Готін О.С. Грязов А.Б. Гук А.П. Дядечко А.О. Земскова О.В. Каджая М.В. Коваль С.С. Лісяний М.І. Макєєв С.С. Нахаба О.О. Новікова Т.Г. Павлов А.І. Потапова А.Г. Робак К.О. Скобська О.Є. Солонович О.С. Чеботарьова Л.Л. popup.nrat_date 2020-04-02 Close