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Information × Registration Number 0217U000506, 0114U001206 , R & D reports Title The experimental studying of the specific action of new bioactive connections and stem cells for the correction of autoimmune damage of a thyroid gland popup.stage_title Head Malova Nataliya Georgiyivna, Registration Date 08-02-2017 Organization State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine" popup.description2 Object of study - immunomodulatory activity and normalizing of thyroid functional effect of fetal stem cells and new sulfur heterocyclic (code KATN and PL-308). Purpose - to develop new approaches to correcting thyroid autoimmune disorders based on experimental studies using new chemical compounds and stem cells. Methods - pharmacological, ELISA, histological, chemical, physical, chemical, biological, statistical. It is shown that experimental autoimmune thyroiditis (AIT) for 6 months. experiment except nonspecific activation of cellular immunity and thyroid function disorders characterized by the development of inflammation and persistent morphological features of autoimmune destruction of the thyroid gland (TG), which displays as a hormonal imbalance is more significant in females. Cryopreserved stem cells (SC) fetal origin show a positive effect on histostructure and thyroid function in rats with induced AIT. The cells are mesenchymal-mesodermal origin (SC-2) are more efficient than fetal liver cells (SC-1). After entering both biologics observed in rats restoration of the structure and functional activity of the thyroid, including normalization of both factions and T4 AT TG. Positive changes more pronounced in males. In term of 1-6 months. observed inhibition of autoimmune aggression and reduce balance of system dysrehulyatornoho immune cells, especially in the group of animals which was administered SC-2. Under the influence of chemical compounds: 3- (4,5-Dyhydrotiazol-2-yl) amide cis-1,2,2-trimethyl-cyclopentane-1,3-dycarbon acid (qatna) and hydrobromide 6- (4'-iodofenil) -2,3-dyhydroimidazo [2,1-b] thiazole (PL-308) in rats with AIT also observed positive changes in the thyroid and immune systems. While the chemicals were less tropic to thyroid parenchyma compared to the UK, against their introduction marked the normalization of the balance of thyroid hormones and certain parts of the immune system, both cellular and humoral, indicating a decrease of autoimmune aggression. The action of the two compounds is unidirectional nature, the impact of PL-308 is more expressive. A more sensitive to chemical compounds thyroid system was female, while their immune system reacts to the introduction of chemical compounds are less active. Make a general conclusion that the use of stem cells is promising in the treatment of thyroid pathologies and chemical compound PL-308 can be considered as an effective non-specific immunomodulator and may be recommended for the development of a potential drug for immunotherapy at AIT. Based on 2 aminotiazol also drafted its original KATN. Defined physicochemical properties and some methods of control and end intermediates. Areas of application - pharmaceutical chemistry, endocrinology. Product Description popup.authors Іващенко О. Бастригіна А. Бречка Н. Бурма Т. Вакула В. Герасименко Л. Гопкалова І. Дубовик В. Завадська Н. Комарова І. Малова Н. Нікішина Л. Селюкова Н. Сергієнко Л. Сиротенко Л. Сова О. Спиридонов А. Хазієв В. Черевко Г. Яременко Ф. popup.nrat_date 2020-04-02 Close