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Information × Registration Number 0217U000723, 0112U003037 , R & D reports Title The structure, selectivity of binding to biological targets and activity of compounds with neurotropic, immunotropic, and antithrombotic activity popup.stage_title Head Andronati S.A., Registration Date 24-02-2017 Organization A.V. Bogatsky, Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 It is shown that the method of separation of racemic mixtures of methyl esters of 3-amino-3-arylpropionovyh acids by forming diastereomeric salts with natural tartaric acid leads to the separation of the two diasteriomeriv individual condition. This method is good for playing ethers beta-phenyl- beta -alanine and beta - (p-fluorophenyl) - beta -alanine. Found that a simple effort to highlight 2R, 3R-tartrate esters S- beta -phenyl- beta -alanine, R- beta - (p-fluorophenyl) - beta -alanine and R- beta - (p-chlorophenyl) - beta - alanine, which is associated with a lower solubility corresponding diastereomers. Determined by HPLC purity obtained optical 2R, 3R-tartrate esters of 3-amino-3-arilpropionovyh acids. Synthesized optically active RGD mimetics - derivatives of 1,2,3,4-tetrahidroizohinolinu. RSA method established molecular structure of 3-R- (4-fluorophenyl) -3 - {[(2-Boc-1,2,3,4-tetrahidroizohinolin-7-carbonyl) amino] propionyl} propionic acid. Product Description popup.authors А. Артеменко А. Замковая А. Карпенко А. Крысько В. Кузьмин В. Ларионов В. Павловский Е. Халимова М. Шибинская Н. Буренкова Н. Головенко Н. Ильюшко О. Крысько С. Андронати С. Бачинский С. Заноза С. Ляхов С. Смульский С. Соболева Т. Кабанова Т. Карасева Т. Михайлова Т. Юрпалова popup.nrat_date 2020-04-02 Close