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Information × Registration Number 0217U000724, 0112U003037 , R & D reports Title The structure, selectivity of binding to biological targets and activity of compounds with neurotropic, immunotropic, and antithrombotic activity popup.stage_title Head Andronati S.A., Registration Date 24-02-2017 Organization A.V. Bogatsky, Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 Study of new derivatives arylpiperazynu of pyrimidine moiety in the terminal part of the molecule at a dose of 15 mg/kg, in biochemical indicators rat blood in acute normobaric hypoxia showed that their action aimed at preserving zhyznediyalnosti and efficiency as the brain, as also of the whole , while in normal conditions, they do not change the biochemical parameters of blood compared to refrens-drug aktoprotektorom bemitylom (33.5 mg/kg). Under the influence of the compounds studied biochemical parameters of blood in acute normobaric hypoxia seek and achieve control values in normal conditions. Condensation halohenovmisnyh naftalevyh anhydrides with diamine synthesized halohenoaminoalkilnaftalimides. Studied compounds synthesized affinity to DNA, found that the inherent naftalimidu dykationnym derivative is a constant association with DNA 1.2 - 1.7 orders of magnitude higher than those for monobasic. Condensation of 2,3-dichloro-1,4-naphthoquinone with the appropriate substituted amines obtained 3-chloro-2- (R-amino) -1,4-naphthoquinone (compound 8) and shown that these compounds are not intercalating DNA, virtually not induce interferon, but significantly enhance the induction of cytokines in vitro when activated cells can consider these compounds as potential imunoad'yuvanty. Product Description popup.authors А. Артеменко А. Замковая А. Карпенко А. Крысько В. Кузьмин В. Ларионов В. Павловский Е. Халимова М. Шибинская Н. Буренкова Н. Головенко Н. Ильюшко О. Крысько С. Андронати С. Бачинский С. Заноза С. Ляхов С. Смульский С. Соболева Т. Кабанова Т. Карасева Т. Михайлова Т. Юрпалова popup.nrat_date 2020-04-02 Close