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Information × Registration Number 0217U000725, 0112U003037 , R & D reports Title The structure, selectivity of binding to biological targets and activity of compounds with neurotropic, immunotropic, and antithrombotic activity popup.stage_title Head Andronati S.A., Registration Date 24-02-2017 Organization A.V. Bogatsky, Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 Synthesized acyloxy- 3-3-alkoxy 3-arylaminamino-, 3aryliden (hetaryliden) -1,2-dihydro-3H-1,4-benzodiazepine-2-ones. The study of compounds derived affinity to receptors benzdiazepines CNS experimental animals by radioligand analysis found that 3-atsyloksy- 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepine-2-ones are selective ligands CBDR CNS and 1 methoxycarbonylmethyl-3- (nitrophenyl) amino-1,2-dihydro-3H-1,4-benzodiazepine-2-ones are selective ligands PBDR (TSPO receptor) and 1 replacement metoksykarbonilmetylnoho substituent on the 1-hidrazynokarbonilmetylnyy leads to loss of affinity to benzdiazepines CNS receptors. For the most affine compounds for CNS TSBDR established internal activity. The study anxiolytic, anticonvulsant, sedative, neuroprotective, analgesic and anti-inflammatory activity of the compounds synthesized highly established compounds with low toxicity, are recommended for advanced study and further implementation in medical practice. Product Description popup.authors А. Артеменко А. Замковая А. Карпенко А. Корнилов А. Крысько В. Кузьмин В. Ларионов В. Павловский Е. Халимова И. Валиводзь М. Шибинская Н. Буренкова Н. Головенко Н. Ильюшко О. Крысько С. Андронати С. Бачинский С. Заноза С. Ляхов С. Смульский С. Соболева Т. Кабанова Т. Карасева Т. Михайлова Т. Юрпалова popup.nrat_date 2020-04-02 Close