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Information × Registration Number 0217U001008, 0112U002107 , R & D reports Title Genotype-phenotype correlation in malignant tumors popup.stage_title Head Filonenko Valeriy Viktorovitch, Доктор біологічних наук Registration Date 05-01-2017 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 SAGE analysis revealed differences in gene expression in glioblastoma and normal brain and proved that 44 genes expressed in at significantly higher levels in tumors including CHI3L1 - representative of the family of IGF, and its increased expression in patients with GB, together with increased expression CHI3L2, can serve as a new molecular markers of glial tumors. We found that CHI3L1 and CHI3L2 modulates the MAPK signaling cascade. The data suggest that over expression CHI3L1 increases the proliferative activity of cells and affect the ability of cells to survive in the absence of attachment to the extracellular matrix. According to the data CHI3L1 can be considered a potential oncogene protein that can be a target of adjuvant therapy for tumors with hiperexpression of CHI3L1. Potential tumor suppressor genes of human kidney light cell carcinoma - NKIRAS1, PPM1M, PRICKLE2, GPXs1, 2, 3, 4, 6 have been identified and the peculiarities of their expression have been studied. Genetic alterations and reducing of expression for NKIRAS1, PPM1M, PRICKLE2 and GPX1 have been detected. The presence of genetic alterations, such as deletions of heterozygous, homozygous deletion and amplification of genes for NKIRAS1, PPM1M, PRICKLE2, GPXs 1,3,4 was confirmed using a web resource cBioPortal. Affine interaction of the fusion protein BCR-ABL with protein partners for understanding the pathogenesis of leukemia with a translocation (9; 22) and in accordance with the development of new approaches to therapy have been studied. The data of the interaction of PH-domain fusion protein BCR-ABL proteins with relevant partners allowed us to determine new areas of study therapy and diagnosis of myeloproliferative neoplasms. Given the existence of a correlation between the expression of MGMT gene encoding for reparative enzyme O6-metylhuanin-DNA methyltransferase and the sensitivity of tumors to therapy with the use of alkyl abundant compounds were studied the molecular basis of the regulation of gene expression at the level of MGMT postatranslational, posttranscriptional and protein modifications. In promoter region and MGMT protein molecule we found potential regulatory sites. The possibility of regulation of human MGMT gene expression by hormones and regulation of enzyme activity by posttranslational modifications have been postulated. Number of tumor-associated antigens of medullary carcinoma have been characterised. The panel of 6 antigens (RAD50, NY-CO-58, PARD3, SAP30BP, SPP1, NY-BR-62), which allows to differentiate groups of patients and healthy women with a sensitivity of 70% and a specificity of 91% for serological analysis of the sera of patients have been selected. Product Description popup.authors Єршов Антон Вікторович Авдєєв Станіслав Сергійович Анопрієнко Ольга Володимирівна Арешков Павло Олександрович Вагіна Ірина Михайлівна Геращенко Ганна Володимирівна Гордіюк Василь Васильович Дибков Михайло Васильович Кіхно Ірина Михайлівна Кашуба Володимир Іванович Киямова Рамзія Галямівна Лукаш Любов Леонідівна Підпала Ольга Володимирівна Рачков Олександр Едуардович Степаненко Олексій Андрійович Строковська Людмила Іванівна Телегеєв Генадій Дмитрович Філоненко Валерій Вікторович Швачко Людмила Павлівна Яцишина Анна Петрівна popup.nrat_date 2020-04-02 Close