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Information × Registration Number 0217U001114, 0111U009944 , R & D reports Title Developing new ways for obtaining geterokondensed systems and directed synthesis of anti-tumor compounds popup.stage_title Head Anatolii F. Popov, Доктор хімічних наук Registration Date 25-01-2017 Organization LM.Litvinenko Institute of Physical Organic and Coal Chemistry popup.description2 The object of study - hetaryl substituted 5-aminopyrazoles, hetaryl substituted pyrazolo [3,4-c] isoquinolines and their synthesis via cyclization reaction. The purpose of work - development of methods of synthesis of pyrazolo [3,4-c] isoquinolines with hetaryl substituents in the pyridine and benzene nuclei; creating a set of technical solutions for the manufacture of compounds with anti-cancer and other types of activity. Research methods - organic synthesis, NMR, IR spectroscopy, thin layer chromatography, and the volume, molecular docking. Formulations developed methods for the synthesis of 1- and 3-hetaryl-4 (3,4-dimethoxyphenyl) -5-aminopyrazole and their corresponding halogen derivatives. Using Pictet-Spengler reaction methodology developed synthesis method pyrazolo [3,4-c] isoquinolines with heterocyclic substituents azine series. The differences in reactivity of hetaryl carboxylic esters in the acylation reaction aryl-acetonitrile and the ways of the aminopyrazole cyclization within modern representations this reaction. Product Description popup.authors Білобров В.М. Бородкін Я.С. Гресько С.В. Коваль Т.С. Матвієнко А.Г. Ніколаєв О.С. Смирнова О.В. Суйков С.Ю. Толкунов А.С. Толкунов В.С. Толкунов С.В. Хіжан О.І. popup.nrat_date 2020-04-02 Close