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Information × Registration Number 0217U001199, 0116U005018 , R & D reports Title High-throughput screening and selection of сlass imidazole antimycotic and antitumor activity. popup.stage_title Head Yemets Alla Ivanivna, Registration Date 27-01-2017 Organization Institute of Food Biotechnology and Cenomics of the National Academy of Sciences of Ukraine popup.description2 25 selected compounds from Life Chemicals libraries that have a maximum rating of affinity for the target, as well as meet the physical and chemical criteria for the selection of drug compounds. Search again promising compounds in the repository of the Institute of Organic Chemistry National Academy of Sciences of Ukraine showed that the previously defined compounds - B0091 and F0478-0477 are dominant. Perfected protocol obtain preparations enriched tubulin dimers suitable for in vitro polymerization reaction. The absolute leader on the strength of the cytotoxic effect of a compound B0091 with a minimum effective dose of 1 micron. It is a promising candidate material for further development of anticancer drugs. By indices DNA damage of tumor cells MCF-7 have the highest cytotoxic activity B0478-0477 drugs and B0091. Product Description popup.authors Білько Д.І. Білько Надія Михайлівна Василовська С. В. Карпов Павло Андрійович Клочкова Ю.О. Литвин Дмитро Іванович Ожерєдов Сергій Петрович Раєвський Олексій Володимирович Співак Світлана Ігорівна popup.nrat_date 2020-04-02 Close