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Information × Registration Number 0217U001888, 0114U001344 , R & D reports Title Effectivenes and safety of the nesteroid antiinflammatory drug and Ca-fntagonists belonging to dihydropyridines under their complex use on the model of rheumatoid artritis acompanied by arterial hyper tension. popup.stage_title Head Seredinskaya Nataliya Nikolaevna, Доктор медичних наук Registration Date 02-08-2017 Organization State Establishment "Institute of Pharmacology and Toxicology National Academy of Medical Science of Ukraine" popup.description2 Diclofenak and Nimesulide don't have hypertensive effect when experimental rheumatoid arthritis is coupled with arterial hypertension. antihypertensive calcium antagonist Amlodipine elicit activity when used alone and I combination with other NSAIDs in the background of comorbid state' using of Diclophenak in the background of comorbid state cause tachyanhythmia in white rats' In the background of conjuncted pathology Nimesulide shows healing effect especially in the time of acute phase of adjuvant arthritis development, which is characterized by heart rate decrease. Dyhydropyridine-derived calcium antagonist Amlodipine strengthen tachyarrhythmia when combined with NSAIDs and don't have antiarrhytmic effect on conditions of coniuncted pathology. In the background of comorbid state pain sensitivity is decrease. Analgesic effect of celecoxib during combined pathology is higher than effects of Diclofenak and Nimesulide. Analgesic use of Amlodipine with Dicrofenak or celecoxib increase analgesic effect of mentioned NSAIDs considerably. Arterial hypertension increase limbs swelling during adjuvant arthritis. Unlike Diclofenak and Nimesulide, celecoxib considerably decrease limhs swelling during comorbid state. Combined use of celecoxib with Amlodipine decrease limbs swelling greatly. Product Description popup.authors Бершова Тетяна Анатоліївна Киричок Лора Михайлівна Мохорт Микола Антонович Омельяненко Зінаїда Петрівна Суворова Олександра Сергіївна Хоменко Василь Станіславович popup.nrat_date 2020-04-02 Close