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Information × Registration Number 0217U002453, 0114U000507 , R & D reports Title Pathophysiological substantiation and development of organ sparing reconstructive and plastic operations for respiratory system malformations in neonates and infants popup.stage_title Head Levitskiy A.F., Доктор медичних наук Registration Date 16-02-2017 Organization National medical university popup.description2 It was found out that airway malformations that appear as organic, functional and compression stenoses were characterized by similar symptoms and clinical course. The pathogenesis is based on the narrowing of the trachea and / or main bronchi, the loss of their stability with violation of permeability, drainage and ventilation functions. Obstructive ventilation disorders, violation of the diffusion of gases and secretory functions of the lungs, along with secondary inflammation lead to the development of respiratory insufficiency, hypoxia and hypercapnia, breach of both respiratori and nonrespiratory lung functions, which may be life-threatening for the child. The conception of syndrome of unstable trachea has been defined. A new concept of the pathogenesis of lung aplasia has been formulated. The anatomical and pathophysiological differences between lung aplasia and agenesis has been established . It was proved thad the pathogenesis of respiratory disorders was caused by impaired patency of airway and disorders of lung ventilation, flotation of the mediastinum, kinking of great vessels, formation of pathological emphysema of single lung with a significant decrease in blood perfusion in the herniated lung segments. This greatly reduces the respiratory system functional reserves. The segmental nature of the lesion in congenital left-sided emphysema (mainly in the apical segments of the left lung) has been established. The role of vascular abnormalities as well as the significant reduction in blood perfusion in the affected segments of the lungs has been proved to be the factors of pathogenesis of congenital emphysema. It was found out that the malformations of lung parenchyma accompanied by mediastinal shift and flotation, result in functional airway stenosis due to their kinking at the area of upper thoracic aperture and suprabifurcation segment as well as its compression by great vessels due to shift of the heart. The result is a violation of compromised lung ventilation with the development of respiratory distress. The indications for use of surgical methods for correction of the malformations of the respiratory system were developed, pathogenetically justified, systemized and concretized based on based on principles organ-sparing principles. Surgical procedures in organic stenosis of the trachea and laryngotracheal stenosis, compression stenosis of the trachea, functional stenosis of the respiratory tract, congenital isolated tracheoesophageal fistula, lung aplasia, congenital emphysema, cystic lesions of the lung and associated malformations, including a combination of malformations of respiratory, digestive, cardio-vascular system and skeleton have been developed and improved. The possibility and expediency of simultaneous operations in children of all ages, including operations with the use of cardiopulmonary bypass have been proved. The long-term results of surgical correction of the malformation of the respiratory system in children were studied . Product Description popup.authors Бензар Ірина Миколаївна Дубровін Олександр Глібович Кривченя Данило Юліанович Левицький Анатолій Феодосійович Метленко Олександр Володимирович Притула Василь Петрович Руденко Євген Олегович Яременко Вадим Володимирович popup.nrat_date 2020-04-02 Close