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Information × Registration Number 0217U002722, 0117U003204 , R & D reports Title Structural control of the reaction direction. Controlled synthesis as the basis for innovative chemical technology popup.stage_title Head Bogza Sergij Leonidovich, Доктор хімічних наук Registration Date 04-09-2017 Organization LM.Litvinenko Institute of Physical Organic and Coal Chemistry popup.description2 The object of study - investigation of derivatives of 2-aminoindolysin, their synthesis and transformation. The aim of the work is to develop common synthetic approaches to the production of functionalized derivatives of 2 (1 H) -aminopentolysin and to study their synthetic transformations and properties of substances in this class. Methods of investigation - organic synthesis, thin-layer chromatography, 1H NMR, 13C NMR IR, UV spectroscopy, chromatographic mass spectrometry, X-ray diffraction analysis, elemental analysis. Conditions for the effective synthesis of a systematic series of 2-aminoindolysin derivatives were first determined by the interaction of electron-deficient acetonitrile and quaternary salts of 2-halopyridines using rare-phase basic catalysis. Processed synthesis methods 2-aminoindolysins without a substituent at position 3, directions of their interaction with a wide spectrum of electrophilic reagents are investigated. For the first time, the region-selectivity of these interactions was detected, which allows us to characterize the above-mentioned 2-aminoindolysins as hidden "push-pool" are variables. The results of the work may be useful in the preparative chemistry of heterocyclic compounds - biologically active substances and the development of new drugs based on them. Product Description popup.authors Богдан Н.М. Хайрулін Андрій Рашидович popup.nrat_date 2020-04-02 Close