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Information × Registration Number 0217U002820, 0115U002587 , R & D reports Title The synthesis of novel bioactive derivatives of azaheterocycles and study of their properties. popup.stage_title Head Brovarets V., Доктор хімічних наук Registration Date 12-12-2017 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 It is shown that during action on 2-aryl-4-(dichloromethylene)-1,3-oxazole-5(4H)-ones with 2-isocyanacetic acid methyl ester and then pyrrolidine, piperidine and morpholine not known earlier derivatives of 5-amino-4,5'-bis-1,3-oxazole-4'-carboxylic acid methyl ester are formed. It is shown that under reaction with hydrazinhydrate 5-(morpholin-4-yl)-2-(4-phthalimidobutyl)-1,3-oxazole-4-carbonitrile product of recyclization fromed - (3-amino-5,6,7,8-tetragidroimidazo[1,2a]pyridin-2-yl)metanone, and in case of removing defence phtalimide group - 2-(5-aminopentyl)-5-(morpholin-4-yl)-1,3-oxazole-4-carbonitrile. In the first time the reaction of 2-acylamino-3,3-dichloroacrylonitrile with C-nucleophiles was investigated, which in case 4-(1-cyclopentyl-1-yl) morpholine led to the formation of new cyclopentyl ketones. Reaction of 1-acylamino-2,2-dichloroacrylonitrile, 1-acylamino-2,2,2-trichloroethyl phosphonic acids and 1-acylamino-2,2-dichloroethenylphosphonium salts with natural alkaloid cytisine studied, as a result a number of new polyfunctional derivatives of cytisine, contained pharmacological 1,3-oxazole fragment, synthesized. Product Description popup.authors І.Н. Яковенко А.М. Корнієнко А.О. Гуренко Б.А. Демидчук В.В. Жирнов В.М. Прокопенко В.С. Зябрєв Г.П. Мруг Е.Р. Абдурахманова К.В. Туров К.М. Кондратюк М.С. Фрасинюк О.В. Головченко О.В. Шабликін О.Д. Качковський О.П. Козаченко О.П. Мітюхін Р.М. Виджак С.А. Чумаченко С.В. Ключко С.Г. Пільо С.Р. Сливчук С.Я. Панчишин Я.І. Простота popup.nrat_date 2020-04-02 Close