Registration Number
0217U003213,
0116U001003
, R & D reports
Title
The investigation of cytogenetic effects peculiarities in radiotherapy patients due to different volume and regimen of irradiation
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Head
Maznyk N.O.,
Registration Date
25-01-2017
Organization
Grigor'ev Institut for Medical Radiology
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Object of study: cytogenetic effects in cultured peripheral blood lymphocytes of uterine cancer patients during radiation therapy with various exposure regimen. The aim: to assess the cytogenetic effects in vivo and ex vivo in lymphocytes of cancer patients following external and internal radiation treatment, depending on the irradiation volume and exposure regimen. Research methods and techniques: cytogenetic analysis of human blood cultured lymphocytes, statistical methods of data processing, microscopes Axioskop, Micros MC300X and Olympus, system ASIS. Theoretical and practical results: it was shown the excess of chromosomal exchanges before treatment over spontaneous level in all groups of patients. The different character of chromosomal type aberrations accumulation in groups of patients depending on the various exposure regimen was found. The monotonic increase of radiation-induced aberrations from beginning to end of treatment in groups of patients following external and combined irradiation and less pronounced changes in these parameters in patients during internal irradiation were demonstrated. These data are of importance for correct assessing the impact of therapeutic irradiation on normal tissues at the chromosomal level. Novelty: new knowledge has been obtained about the character of chromosome damage outcome in lymphocytes of uterine cancer patients during radiation therapy depending on the exposure regimen. The effectiveness of implementation: is not present. Area of application: radiobiology, radiation therapy.
Product Description
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Ірха О.Е.
Грановська Г.І.
Дашкова С.А.
Забобоніна Л.В.
Колпакова Л.К.
Кругова І.М.
Мазник Н.О.
Немальцова К.В.
Нестеренко Г.С.
Павліченко Ю.В.
Пшенічна Н.Д.
Пшишевська Л.А.
Святенко Н.І.
Сипко Т.С.
Старенький В.П.
Сухіна О. М.
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2020-04-02
