Registration Number
0217U004104,
0116U006678
, R & D reports
Title
Structural control of the reaction direction. Controlled synthesis as the basis for innovative chemical technology
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Head
Bogza Sergij Leonidovich, Доктор хімічних наук
Registration Date
13-01-2017
Organization
LM.Litvinenko Institute of Physical Organic and Coal Chemistry
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Object of study - hetaryl sudstituted 5 aminopyrazoles, pyrazolo [3,4-c] isoquinolines, their synthesis and cyclization reactions. Aim of research - to develop methods for the synthesis of pyrazolo [3,4-c] isoquinoline with hetaryl substituents in pyridine and benzenovomu cores; creation of complex engineering solutions for the production of compounds with anti-cancer and other types of activity. Research methods - Organic synthesis, NMR, IR spectroscopy, thin layer chromatography and volume, molecular docking. Processed preparative methods of synthesis of 1- and 3-hetaryl-4- (3,4-dymetoksifenil) -5-aminopirazoliv and their respective haloyidpohidnyh. Using the methodology of response Pictet-Shpenhera the method of synthesis of pyrazolo [3,4-c] isoquinoline with heterocyclic substituents azynovoho series. Detected differences hetarylnyh esters reactivity in acylation reactions arylatsetonitryliv and the ways of cyclization aminopirazoliv processes within the modern ideas of Spengler reaction. The results may be useful in preparative chemistry of heterocyclic compounds - biologically substances and development on the basis of new medicines. Keywords Tsianoketon 1.3-4-aryl-5-aminopirazol, cyclization, pyrazolo [3,4-c] isoquinoline, heterylnyy substituent NMR anticancer activity
Product Description
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Богдан Н.М.
Бондаренко О.В.
Бородкін Я.С.
Коваль Т.С.
Родигін М.Ю.
Суйков С.Ю.
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2020-04-02
