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Information × Registration Number 0217U004176, 0114U003036 , R & D reports Title To study the clinical and epidemiological features of drug resistant tuberculosis and develop measures to optimize epidemiologikal surveilance popup.stage_title Head Tkach Olena, Registration Date 19-01-2017 Organization State Institution "Lviv Research Institute Epidemiology and Hygiene Ministry of Health of Ukraine" popup.description2 Object of study: patients with drug-resistant pulmonary tuberculosis, history, survey data, statistical reporting. Methods: Epidemiological, clinical, X-ray tomography, bacteriological, immunological, biochemical, statistical, analytical. The goal: to improve epidemiological surveillance of drug-resistant pulmonary tuberculosis in the current epidemic. An integral evaluation of the epidemiological situation HRTB stratification and territories in terms of regions of Ukraine epidnebezpeky. Established initial growth rate (48.1% vs. 37.4%) and secondary (58.9% vs. 65.1%) of drug resistance. In its structure - stated a significant increase in the share of primary (21.3% vs. 12.9%) and secondary (41.1% vs. 28.1%) multyrezystentnosti Office. The trends bacterial growth in the incidence of tuberculosis relapse and its average annual growth rate of 0.6%, the share of new HRTBL (2.8%) and repeat (2.0%) cases of pulmonary TB MR (2, 5% and 4.0%, respectively), tuberculosis, AIDS combined (0.5%), incidence of contact persons in the centers (0.6%). Forecasted high growth MRTBL in the Northern, Southern, Eastern and Central regions. Established prognostically significant factors that reduce the effectiveness of treatment, increase common abandoned destructive forms (54.0% and 46.0%, respectively); low incidence of bacterial suspension (82.1% and 72.8%); high specific percentage distribution of strains of Mycobacterium tuberculosis profile HRSE (36,8% and 34,6%) and extended multyrezystentnistyu (15.8% and 32.1%); the presence of comorbidity (34.7%); low adherence to treatment - treatment interrupted in the first 4 months. (11.8% and 23.0%), the rate of 8 months. CT accomplishes only half of patients (53.8% and 51.7%); immunosuppressive states with a decrease of more than 30.0% of T-lymphocyte pool of proliferative activity, phagocytic deficiency due to 30-50,0% decrease in lysosomal protein content granulocytes, tuberculin energy is specific T lymphocytes; high level of intoxication; excessively severe acute phase mobilize the body's defenses, increase the activity adenozyndezaminazy over 22.6 units. act., ceruloplasmin level - 2.8 mlmol / l, haptoglobin - 2.2 g / L ratio De-Ritisa than 1.5, antioxidant deficiency, antyproteolitychnoho potentials. Critical deviations range established markers as predictors feasibility of individual correction of the violations. Correction algorithm therapeutic measures in patients with pulmonary XDR TB with a poor prognosis. Product Description popup.authors Лаповець Наталія Євгенівна Мажак Квітослава Деонізівна Мельник Леся Ярославівна Писаренко Євген Іванович Платонова Ірини Львівна Ткач Олена Андріївна Чура Галина Євгенівна Щурко Галина Василівна popup.nrat_date 2020-04-02 Close