Registration Number
0217U004415,
0116U004755
, R & D reports
Title
Photosensitive, fluorescent and fluorine-containing biologically active peptidomimetics new approaches for diagnosis and therapy.
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Head
Komarov Igor,
Registration Date
02-02-2017
Organization
Taras Shevchenko Kiev University
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The object of study: Design and synthesis of amino acids that are photosensitive, fluorescent, conformationally restricted and / or containing fluorine-containing substituents; introduction of synthesized amino acid composition of known biologically active peptides by solid phase peptide synthesis; studying the biological properties derived peptides (peptidomimetics) and their pharmacological characteristics in order to use them in the diagnosis and treatment of infectious diseases and cancer. Objective: design, synthesis and development of techniques used in the diagnosis and treatment of infectious diseases and cancers such peptides are modified fluorine-containing residues, fluorescent or photosensitive amino acids. Methods: organic synthesis, computer simulation, anaziz by physical methods. There were design and synthesis of new fluorine-containing fluorescent and photosensitive amino acids. New Synthesis of fluorine-containing amino acids (analogues of natural amino acids - valine, leucine, isoleucine, methionine and lysine) meet all the requirements of compounds that can be used as labels for 19F-NMR spectroscopy - have a hard hydrocarbon skeleton monofluorozamischeni obtained in optically active form, Fmoc- reserved to be used in solid-phase peptide synthesis.
Product Description
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Комаров І.В.
Пивоваренко В.Г.
Радченко Д.С.
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2020-04-02
