Registration Number
0217U004458,
0116U002527
, R & D reports
Title
Mechanisms of regulation of metabolic processes in the body under conditions of pathological conditions
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Head
Ostapchenko L.,
Registration Date
03-02-2017
Organization
Taras Shevchenko Kiev University
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The obtained scientific results showing that obesity affects the state microbes oty colon with a significant reduction in the number of the genus Lactobacillus, simultaneously with the increase in the number of representatives aerobic types of E. coli and S. aureus. It is shown that the development of obesity is associated with changes Cytomorphological indicators spleen, thymus and lymph nodes of regional, which indirectly indicate the activation of the immune response by Th2 type female animals and the Th1 type - male animals. For obesity is inhibiting contractile activity of skeletal muscles, maximum power response, the fall of the overall force reduction and integrated power muscle that is associated with disorders of neuromuscular transmission and the changes that occur in muscle cells . The analysis subunit (26S- and 20S) of proteasomes in the cells of various organs and tissues, and investigated their redistribution in conditions of obesity. Comprehensive study of biological effects of an extract of Phaseolus vulgaris husk confirmed its effec-tive antidiabetic effect. The results justify the appropriateness of the last one-Use fitosyrovyny in medical practice for the treatment of diabetes and its complications. The results indicate that the presence of type 2 diabetes has reinforced negative changes causing the development of ischemic stroke. Zanoah, yet significant differences in the functioning of hemostasis and metabolism of serotonin in the bloodstream. It is shown that kisspeptyn neyrotsyty activate astrocytes and al-kuatnoho preoptical nuclei of the hypothalamus and 3-month-old rats, whereas receptor blocker KP does not inhibit morphofunctional state neyrotsytiv 3-month-old animals. Studies were conducted on the proposed topics, show promise in terms of developing new biotech products directed action. Results obtained on preventive medical action powder Trigonella foenum graecum L. and Phaseolus vulgaris extract on the development of obesity and diabetes 1 show promising results for the use of biotechnological products create directional correction of these pathologies. The data obtained in the study of potential mechanisms underlying the devel-opment of various pathological conditions indicate the possibility of developing algorithms for diagnostic test kits and predictive manipulation to improve the diagnosis and correction of metabolic disorders functioning of the body.
Product Description
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Є.Тукалєнко
І.Зима
В.Верещака
В.Конопельнюк
В.Сорока
В.Шепелевич
Д.Ноздренко
К.Кременецька
М. Тимошенко
Н.Нурищенко
Н.Філімонова
П.Янчук
С.Весельський
Т. Коваль
Т.Вовк
Т.Галенова
Т.Довбинчук
Т.Червінська
Ю.Бабенюк
Я. Раєцька
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2020-04-02
