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Information × Registration Number 0217U004473, 0115U001404 , R & D reports Title Development of the system of fast screening of DNA-binding compounds for the search of inhibitors of nucleic acids biosynthesis enzymes as potential antitumor and antimicrobial agents popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 03-02-2017 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 A series of new functionally substituted derivatives of acridines and porphyrins as potential DNA ligands were obtained and their interaction with duplex and quadruplex DNA was studied by the method FID in microplate format. DC50 parameters (ligand concentration at which it substituted 50% of the dye in its complex with NA) and binding costants of ligands with various forms of DNA were determined. High DNA binding affinity of numerous new compounds was established. Product Description popup.authors Ільченко Микола Миколайович Алексеєва Інна Володимирівна Дубей Лариса Василівна Костіна Валентина Григорівна Костенко Олександр Миколайович Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Негруцька Валентина Володимирівна popup.nrat_date 2020-04-02 Close