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Information × Registration Number 0217U004501, 0116U002559 , R & D reports Title Design, synthesis and study of new heterocyclic compounds to create promising drugs with a wide spectrum of action popup.stage_title Head Khilya V.P., Registration Date 06-02-2017 Organization Taras Shevchenko Kiev University popup.description2 The report on the research: 102 p., 109 Figures, 3 Tables, 1 application source, 124 references. The object of study: nitrogen-, oxygen- and sulfurcontaining heterocecles. Objective: To search and develop the optimum formulations of synthesis methods for studying the structure, physical and chemical features of the new O-, S-, N-containing heterocyclic systems and carbocyclic systems with active functional groups and a wide range of performance to address the actual problems of medicine, biology, nanotechnology and photonics. Methods: Methods for the synthesis of model organic compounds, heterocyclic compounds; NMR, IR, UV, fluorescence spectroscopy; mass spectrometry and gas chromatography; Methods of synthesis at high pressure and under an inert atmosphere; X-ray diffraction and elemental analysis. A comprehensive literature search on the synthesis of isothiazolidine-1,1-diones and isothiazolin-2,2-diones, methods of synthesis, properties, and biological activity of 3-hetarylhroman-4-ones, methods of heterocyclization based on -halo- -unsaturated ketones heterocyclic series were carried out. The most promising sites were identified for further use in the synthesis of heterocycles. The effective methods for the synthesis were developed for: ?6-isothiazolidines and studied their reactions of acylation, condensation, bromination and reduction; thiadiazole analogs of isoflavones and held modification 7-hydroxy-3-(5-phenyl-1,3,4-thiadiazol-2-yl)-6-ethylchromone, neoflavones with N-containing heterocycles and studying of anticancer activity of Diels-Alder adducts in a pyrano[2,3-h]isoflavone series; 2-(1H-pyrazol-3-yl)phenoles; 3-aryl-3,4- dihydroisocoumarines with fragments of naturally occurring amino acids; approaches to annulation of pyrane ring cores to chromone, coumarine and isocoumarine; biologically active derivatives of pyrrolidine and pyrrolidone and found them most efektivnost against the growth of Mycobacterium tuberculosis than GEQ. The interaction of alloperine with glycidyl ethers of isoflavones was studied. The methods of administration of triftorometilnoy group in the furane, quinoline and their heteroaromatic analogues were found. The synthesis of pharmacophore models (heterocyclic carboxyamidines) to create powerful antagonists, proton-sensitive channels was performed on the basis of molecular docking method. The results of research are introduced in the educational process of the Faculty of Chemistry of the Kyiv National Taras Shevchenko University. Product Description popup.authors Єгорова Т.В. Бійцева А.В. Бойко О.М. Горбуленко Н.В. Добриднєв О.В. Кіндер Т.Д. Кисіль А.І. Левков І. В. Любчук Т.В. Матвіюк Т.В. Москвіна В.С. Пласконь А.С. Потіха Л.М. Тарасюк Т. М. Хиля В.П. Цапко М.Д. Шилін С.В. Шокол Т.В. popup.nrat_date 2020-04-02 Close