Registration Number
0217U004962,
0115U006640
, R & D reports
Title
Experimental and clinical analysis of mechanisms of paroxysmal state in conditions of certain brain structures hyperactivation
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Head
Vastynov Ruslan,
Registration Date
05-12-2017
Organization
Odesa National Medical University
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The analysis performed revealed direct dependence of frequency of development of spontaneous spasms in rats on duration of the acute pilocarpine-induced seizures. It is proved that initiation of EEG-activity in a brain of part of rats by structures of frontal bark during spontaneous convulsive activity testifies to need of further research of mechanisms of attraction of these educations for the delayed period of the chronic pilocarpine-induced convulsive syndrome, and also to difficulties, ambiguity of the treatment and systemacity of a complex of changes developing in a brain of rats in the delayed period of the pilocarpine status epilepticus. Firstly it was shown diazepam, phenobarbital and valproic acid antiepileptic efficacy in conditions of pilocarpine-induced seizures. Dyphenilgidantoin and carbamazepine have no influence on development of the pilocarpine-induced seizures.
Product Description
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Бабій Валентина Павліна
Бильський Дмитро Віталійович
Вастьянов Руслан Сергійович
Гуркалова Інна Павлівна
Кірчев Владислав Віталійович
Котюжинська Світлана Георгіївна
Крепец Юлія Сергіївна
Кузьменко Інна Анатоліївна
Муратова Тетяна Миколаївна
Остапенко Ігор Олегович
Погулич Юлія Володимирівна
Прищепа Олена Олександрівна
Савицький Іван Володимирович
Садовимй Олександр Сергійович
Стоянов Олександр Миколайович
Топал Марина Михайлівна
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2020-04-02
