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Information × Registration Number 0217U006009, 0114U001168 , R & D reports Title To develop the methods of differential treatment of hypertensive patients at very high risk of obesity and impaired glucose and purine metabolism. popup.stage_title Head S. Koval, Registration Date 25-01-2017 Organization Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine" popup.description2 The object of the study - patients with arterial hypertension (AH) 2,3-th degree very high risk with abdominal obesity (AO) in combination with disorders of carbohydrate metabolism (impaired glucose tolerance and/or hyperglycemia on an empty stomach, type 2 diabetes) and purine (hyperuricaemia (HUE)) exchange. Research methods: clinical, biochemical, immunoassay, instrumental. The results of the study. It is shown that one of the rational approaches to the treatment of patients with hypertension very high risk of AO and disturbances of carbohydrate and purine exchanges is a phased treatment option appointment in the first phase combination of a blocker of receptors of angiotensin II olmesartan and calcium antagonist third generation lercanidipine followed by the addition, in the case of failure to reach target level of blood pressure (BP), a highly selective beta-blocker with vasodilatatory effect of nebivolol and indapamide,a tiazid like diuretic. This therapeutic approach allows to increase the treatment efficiency up to 90% and to keep the achieved efficiency is not less than one year. Conducting one year of combined antihypertensive and lipid-lowering therapy leads to a significant decrease of blood levels angiopoethin -2 in hypertensive patients with AO who had achieved target BP levels. It is shown that in hypertensive patients with type 2 diabetes conducting antihypertensive and lipid-lowering therapy as antidiabetic drugs metformin in combination with dapagliflozin in contrast, metformin combination with gliclazide, gives the opportunity to have a significantly greater percentage of patients to achieve target BP levels, lower body mass index and to reduce the levels of uricemia). According to the results of annual studies designed informative ways of predicting the course and effective methods for the treatment of hypertension, which occurs on the background of AO, based on the data on metabolic disturbances and alteration of the production of key regulators of angiogenesis through a highly complex mathematical models. Product Description popup.authors Божко В.В. Гудков С.М. Дунаєвська М.М. Зоренко Н.В. Кірієнко М.В. Кірюхіна О.В. Конькова В.С. Корнійчук І.А. Милославський Д.К. Мисниченко О.В. Пенькова М.Ю. Снігурська І.О. Старченко Т.Г. Циганков О.І. Щенявська О.М. Юшко К.О. popup.nrat_date 2020-04-02 Close