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Information × Registration Number 0217U007242, 0117U004992 , R & D reports Title Peptides derived from the Antarctic scallop Adamussium colbecki as a potential means of correcting metabolic disorders of the body caused by the development of obesity popup.stage_title Head Savchuk Olexiy, Registration Date 27-12-2017 Organization Taras Shevchenko Kiev University popup.description2 In the course of the research, the conditions for the enzymatic hydrolysis of the tissues of the anhydrone hydrobionts tissue were selected, which allowed to obtain a solution of peptides in the range of molecular weights from 5 to 0.5 kDa and the absence of protein molecules and oligopeptides with molecular weights above 5 kDa; the isolated peptides retained their functional activity and exhibited stability in the range of pH from 4 to 10 and the ionic strength of the solution was 23 mS. As a result of researches, it was shown that the introduction of peptide solutions to animals on a high calorie diet caused a decrease in the amount of feed consumed per day, accompanied by less pronounced weight gain and a decrease in the body mass index, compared with those for rats that were only on High-calorie diet. The revealed changes were accompanied by the normalization of resistin content in adipose tissue and a decrease in the content of resistin and serum in blood serum compared with obesity. It was found that the use of peptide solution causes the normalization of glucose concentration, the content of glycosylated hemoglobin and insulin, considered as informational markers for the development of insulin resistance. The influence of peptides on the functioning of the peripheral serotoninergic system is revealed, which is manifested in the normalization of monoamine oxidase activity, reduction of serotonin content and increase of the content of tryptophan. The application of peptide solution contributed to the normalization of the total prooxidant-antioxidant balance. The increase in the content of non-protein SH groups was also observed on the background of decreasing the content of protein-bound SH-groups in adipose tissue and serum. The revealed changes were accompanied by an increase in superoxide dismutase activity, while catalase activity remained at the control level. The application of the peptide solution affected the cytokine profile, namely, the decrease in the concentration of pro-inflammatory cytokines IL-1?, IL-6, IFN-?, TNF-? below the control parameters and an increase in the concentration of anti-inflammatory cytokine IL-10. The obtained results substantiate the expediency of using these peptides to create on their basis pharmacological preparations of prophylactic and therapeutic action, biologically active additives or functional foods.5481 Product Description popup.authors Вовк Т.Б. Галенова Т.І. Ракша Н.Г. Юрченко А.В. popup.nrat_date 2020-04-02 Close