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Information × Registration Number 0218U000050, 0117U004312 , R & D reports Title To estimate spectrum of quantity, structural chromomal abnormalities in bone marrow cells at diagnosis of B-cells chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) and comparison with clinico-haematological indexs popup.stage_title Head Andreieva Svitlana V., Registration Date 16-01-2018 Organization State Institution "Institute of Haematology and Transfusiology of NAMS of Ukraine" popup.description2 Object: interphase nuclei and metaphase chromosomes of bone marrow cells at diagnosis of B-cells chronic lymphocytic leukemia (B-CLL) (170 patients) and multiple myeloma (ММ) (103 patients). Methods of investigation: karyotyping, i-FISH, clinical, haematological, morphologycal. Aim: to estimate spectrum of quantity and structural chromomal abnormalities in bone marrow cells at diagnosis of B-CLL and MM . Results deletions are predominated between structutal rearrangements. Chromosomes 17 and 11 (karyotyping), genes ATM nad TP53 (i-FISH analysis) in B-CLL, chromosomes 13 and 17 in MM more often involved in structural rearrangements. More prognocticaly unfavourable aging categories were groups older 50 years. In B-CLL and MM more often unfavourable genetic prognosis groups were registered with i-FISH method (68,4 % and 35,4 %, respectively). Avialability of quantity and structural chromosomal abnormalities can evidence about multilevel mechanism to form of abnormal karyotype at diagnosis of B-CLL and MM. Medicine.5481 Product Description popup.authors Корець Катерина Веніамінівна Сівкович Світлана ОЛексіївна popup.nrat_date 2020-04-02 Close