Registration Number
0218U000379,
0115U003003
, R & D reports
Title
Choosing the tactics of treatment of bone metastases with 153 Sm-oxabifore for reducing of the complication risk
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Head
Grushka G.V.,
Registration Date
26-01-2018
Organization
State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine"
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The object of study: a toxic effect of radionuclide therapy (RNT), clinical, laboratory and morphological properties. The purpose of study: to improve the efficiency of radionuclide therapy of bone metastases by reducing the frequency and extent of complications by individualizing the selection regimen. Research methods and equipment: clinical, laboratory (determination of the level of white blood cells, hemoglobin, platelets, granulocytes), radiation, radionuclide 99mTc-Pyrphotech and 153Sm-oksabifor, dosimetric and statistical studies. Equipment: Gamma Camera, radiometer, X-ray machine, CT scanner, an automatic analyzer. Theoretical and practical results: there was a high degree of correlation between the introduced specific activity and the absorbed dose on the red bone marrow; between the absorbed dose on the red bone marrow and the cumulative activity in the bone. The ratio between the absorbed dose to the red bone marrow, the individual parameters of the pharmacokinetics of 153Sm-oxabiphor and the anatomical features of the treated patients was obtained, which allows to determine the specific activity of the radiopharmaceutical (RFP) for subsequent RNT courses, taking into account the coefficient of retention of the RFP and the coefficient of variability of the trabecular bone volume of lumbar vertebrae L2-L4. Recency: for the first time it has been proved that for the individualization of treatment of bone metastases, i.e. the choice of individual (optimized) for each patient the therapeutic activity of 153Sm-oxabiphor, it is advisable to carry out a prognostic assessment of the absorbed dose on red bone marrow during previous RNT courses, taking into account the coefficient of retention of the RFP and the coefficient of variability of the trabecular bone volume of lumbar vertebrae L2-L4. The effectiveness of the implementation: it consists in reducing the number of RNT courses, which reduces the cost of treatment for 2000-4000 UAH. Scope: radiology, oncology.
Product Description
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Аверьянова Л.О.
Аврунін О.Г.
Астап’єва О.М.
Боброва В.М.
Грушка Г.В.
Кобзар Т.І.
Коломацька В.В.
Кондрашова О.I.
Луховицька Н.І.
Насонова А.М.
Підченко Н.С.
Павліченко Ю.В.
Паскевич О.І.
Поповська Т.М.
Ревенкова С.І.
Савченко А.С.
Стадник Л.Л.
Тихоліз О.М.
Ткаченко Г.І.
Ткаченко Ю.Г.
Черкаско Л.В.
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2020-04-02
