Registration Number
0218U002126,
0116U002642
, R & D reports
Title
Oksovmischuyuchi modified derivatives of piperidine and piperazine as promising antidiabetic drugs.
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Head
Falaleeva Tatyana,
Registration Date
19-01-2018
Organization
Taras Shevchenko Kiev University
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Object of Study: New heterocyclic compounds as promising compounds for the treatment of type 2 diabetes associated with obesity. The purpose of the work is the development of innovative chemical compounds - candidates for drugs using molecular high-performance screening (VPS) in cellular and biochemical systems, as well as related bioanalytical studies, studies of pharmacological efficacy with specific secondary biochemical and cellular test systems, as well as experiments on animals Methods of research - chemical, physiological, biochemical, immunological. Synthetic heterocyclic compound Z56822977 2- [4- (benzyloxy) phenoxy] acetic acid with specific physical, chemical and biological characteristics was synthesized. The results of virtual and molecular high-performance screening on the targets of GPR 119, GPR 40 and SIRT6 of new synthetic heterocyclic compounds for the treatment of type II diabetes mellitus were obtained. The influence of Z56822977 2- [4- (benzyloxy) phenoxy] acetic acid on parameters of carbohydrate, lipid and protein metabolism, cytokine profile / antioxidant system of blood in obese rats complicated by type II diabetes mellitus was studied. The prophylactic and therapeutic effect of Z56822977 2- [4- (benzyloxy) phenoxy] acetic acid has been proven to prevent the development of experimental obesity complicated by type II diabetes mellitus. It was found that the administration of Z56822977 to obesity rats led to an improvement in the prooxidant-antioxidant status. The obtained data indicate the development of the active phase of inflammation and the detection of the terminal termination of this progeny in adulterous animals, which, in the light of changes in conventional biochemical markers, can confirm the involvement of the inflammatory process in the development of cytomegaly pathologies in the background of obesity. In the course of studies, it has been shown that Z56822977 exhibits anti-inflammatory properties, indicating the possibility of correction of inflammatory processes in the body. It has been shown that the administration of Z56822977 normalizes metabolism in rats with obesity induced by sodium glutamate, which confirms the normalization of protein-lipid and carbohydrate metabolism indices.
Product Description
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Береговий С.М.
Бойко Олександр Миколайович
Гайда Людмила Миколаївна
Желуденко Микола Володимирович
Зозуля Сергій Олексійович
Молочек Н.В.
Мороз Юрій Сергійович
Преображенська Тамара Дмитрівна
Совінайнен Л.П.
Ткаченко Антон Миколайович
Фалалєєва Тетяна Михайлівна
Хілько Тетяна Дмитрівна
Цирюк Олена Іванівна
Юрченко О.В.
Якубцова Ірина Володимирівна
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2020-04-02
