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Information × Registration Number 0218U003037, 0115U001404 , R & D reports Title Development of the system of fast screening of DNA-binding compounds for the search of inhibitors of nucleic acids biosynthesis enzymes as potential antitumor and antimicrobial agents popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 12-01-2018 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Biological activity of duplex and quadruplex (G4) DNA ligands found at the previous stage and new compounds was studied in enzymatic test systems in vitro based on topoisomerasde I and telomerase, respectively. Inhibitors of both enzymes were found, including active compounds with IC50 in the range 1.1-1.8 uM. The dependence between the structure of compounds, level of binding tovarious forms of DNA and inhibition efficiency was analyzed. Positive correlation between ligand affinity to duplex and G4-DNA and activity with corresponding enzymes was established. Product Description popup.authors Ільченко Микола Миколайович Алексеєва Інна Володимирівна Дубей Лариса Василівна Костіна Валентина Григорівна Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Негруцька Валентина Володимирівна popup.nrat_date 2020-04-02 Close
R & D report
Development of the system of fast screening of DNA-binding compounds for the search of inhibitors of nucleic acids biosynthesis enzymes as potential antitumor and antimicrobial agents
Head: Dubey Igor. Development of the system of fast screening of DNA-binding compounds for the search of inhibitors of nucleic acids biosynthesis enzymes as potential antitumor and antimicrobial agents. (popup.stage: ). Institute of Molecular Biology and Genetics of NASU. № 0218U003037
1 documents found

Updated: 2026-03-28


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