Registration Number
0218U003069,
0116U002527
, R & D reports
Title
Mechanisms of regulation of metabolic processes in the body under conditions of pathological conditions
popup.stage_title
Head
Ostapchenko L.,
Registration Date
16-01-2018
Organization
Taras Shevchenko Kiev University
popup.description2
The development of diabetes is accompanied by a violation of contractile muscle activity, which manifests itself in a change in their biomechanical indices. With diabetes, there is a significant dysfunction of the transfer of the stimulation signal to the muscle as an efector. 18 BRCA1 5382 insc mutations (5.9 ± 1.3%) were identified among 306 patients with ovarian cancer in Ukraine. For the first time, the features of the kinetics of DNA yield during electrophoresis of nucleotides obtained from blast-transformed lymphocytes at different stages of the cell cycle (G1 and G2) were studied and the possibility of using a comet electrophoresis to study the reorganization of the looping DNA domains with changes in functional cell states was demonstrated. For the first time, it has been established that ceftriaxone-induced changes in the content of CMLC and CLCFA-specific receptors and transports are accompanied by prolonged shifts in the oxidative-antioxidant balance of the colon mucosa, activation of the redox-sensitive transcription factors Egr-1, Sp-1, HIF1? and lead to prolonged changes in the composition of mucus glycoproteins, and, as a result, increased sensitivity of the intestinal barrier to ulcerogenic factors. The dopaminergic system of the brain can be involved with the involvement of D1 receptors of dopamine to realize the stimulating effects of melatonin on the central structures of the hypothalamic-thyroid complex in the evening, and on the thyroid gland at night. The data of the conducted researches show that in the esophagus of rats after acid burn of 2 degree the activity of proteasomes increases in comparison with intact tissues. This increase in proteasome activity is due to the intensification of intracellular proteolysis processes in burn wounds.
Product Description
popup.authors
Є.Тукалєнко
І.Зима
В.Верещака
В.Конопельнюк
В.Сорока
В.Шепелевич
Д.Ноздренко
К.Кременецька
М. Тимошенко
Н.Нурищенко
Н.Філімонова
П.Янчук
С.Весельський
Т. Коваль
Т.Вовк
Т.Галенова
Т.Довбинчук
Т.Червінська
Ю.Бабенюк
Я. Раєцька
popup.nrat_date
2020-04-02
