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Information × Registration Number 0218U003271, 0117U000624 , R & D reports Title Investigation of mechanisms of violations of BRCA1 / 2 - dependent DNA repair in ovarian cancer patients exposed to ionizing radiation due to the Chornobyl accident. popup.stage_title Head Klymenko Sergij, Доктор медичних наук Registration Date 30-01-2018 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 A research object are genes of BRCA1/2, algorithms of prognosis of mutational status. The aim of the work is to define mutational status of genes of BRCA1 and BRCA2 for women with ovaries cancer and to test the algorithms of prognosis of carrier of mutations. Research methods - medical and genetic counseling, molecular genetic studies, methods of mathematical statistics. The sumples of venous blood are got from patients of different age with ovaries cancer, from that genome DNA is exstracted. Frequency of mutations 185delag, 5382insc, 4153dela, 300t>G in the gene of BRCA1 and 6174delt in the gene of BRCA2 was determined. It was 13,3%. Frequency of positive family anamnesis for ovaries cancer and/or brest cancer in the investigated cohort was19%. Family anamnesis correlates with BRCA- positive status. According to prognostic results of mutations the best discriminatory ability in identification of reliable BRCA- positive and BRCA- negative persons in the investigated cohort has a model of BOADICEA and Manchester ball system. The algorithms of Penn II and Myriad are confessed not enough effective. Product Description popup.authors Бичкова Г.М. Міщенюк О.Ю. Мехеда Л.В. Рибченко Л.А. Стефанович Г.В. popup.nrat_date 2020-04-02 Close