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Information × Registration Number 0218U005006, 0115U000688 , R & D reports Title Association of allelic polymorphism of "ectopic calcification genes" with the development of common cardiovascular diseases and their complications popup.stage_title Head Ataman Alexandr Vasilievich, Registration Date 05-02-2018 Organization Sumy State University popup.description2 In the course of the study, new knowledge was obtained on the role of genetic factors, in particular, single nucleotide polymorphism of genes, in the development of major complications of sclerotic arterial lesions - acute coronary syndrome (ACS) and ischemic atherothrombotic stroke (IATS). The essence and novelty of the results are that there is a certain association between the polymorphic variants of some "anti-calcinogenic" genes and the frequency of development of the above complications of arteriosclerosis among representatives of the Ukrainian population. Thus, the relationship between ACS and polymorphic variants of GDR (BsmI), GGCX (Arg325Gln) and VKORC1 (T2255C) genes was revealed. In particular, the risk of GCS in the homozygote for the minor allele for BsmI (P=0.031), T2255C (P=0.012) and Arg325Gln (P=0.037) polymorphisms is approximately 2 times higher than compared with homozygotes by the main allele. An association between IATI and a polymorphic variant of the VKORC1 gene (T2255C) has been identified. In the homozygote for the minor allele C/C (T2255C polymorphism), the risk of the disease is 2.2-times, if compared with homozygotes by the major allele (T/T) (P=0.013). It is established that the influence of the genetic factor on the development of cardiovascular and cerebrovascular pathology has sexual characteristics. In men with B/B genotype (polymorphism of the BsmI of the VDR gene), the risk of ACS is 2.7 times higher than that of the homozygote in the minor allele (b/b) (P=0.013), and in males who are carriers C/C genotype (polymorphism T2255C of the VKORC1 gene), the risk of IATS is 2.5 times higher than that of persons with genotype T/T (P=0.023). For the first time, the distribution of alleles and genotypes for K121Q polymorphisms of the ENPP1 gene, in practically healthy individuals and patients with ACS in the Ukrainian population was investigated. The association of polymorphisms of genes of ectopic calcification inhibitors and activators with SCS in patients with different body mass index (BMI) polymorphisms has been analyzed. In patients with SCS that have K/K genotype, violations of the lipid plasma spectrum and coagulation of blood have been detected, indicating a greater tendency both to the development of atherosclerosis and to its complications. The influence of the genetic factor on the development of cardiovascular and cerebrovascular pathology has sexual characteristics. Female subjects homozygous for the minor allele A/A (G-7A polymorphism of the MGP gene) are 5.6 times more likely to suffer from ACS (P=0.015) and 6.6 times for IATS (P=0.017) than female carriers of the main allele (G/A+G/G). The association of a number of investigated polymorphisms with some risk factors of corticosteroids: body mass index (BMI), arterial hypertension, smoking, stressful occupations was revealed. It has been shown that the polymorphism of A69314G of the TNAP gene is associated with the development of GCS: the risk of ACS in carriers of the minor allele for A69314G polymorphism is 2.2 times higher than that of the homozygote for the major allele, and the risk of ACS in males with A/G+G/G genotype is 2.19 times higher than in patients with A/A genotype. The risk of the occurrence of ACS in smokers, carriers of the minor allele (A/G+G/G), is almost 3.4 times higher than in the homozygote for the major allele (A/A). The connection between the second exon of the BMP-2 gene and the development of complications of ACS was studied. There was no significant difference in the distribution of genotypes between patients with complications and those who had a disease without complications. However, the association with the development of complications of ACS was found in male patients (P=0.018); patients without dislipoproteinemia of atherogenic nature (P=0.038) and without obesity (P=0.016); of patients who smoke (P=0.021). Based on the results obtained, a general conclusion was reached on the existence of a link between some allelic polymorphisms of individual gonadotropic calcifications and the complications of sclerotic arterial lesions as well as external factors of their risk. It greatly broadens and deepens scientific ideas about the influence of hereditary factors on the propensity to the emergence and development of common cardiovascular diseases. Product Description popup.authors Атаман Олександр Васильович Гарбузова Єлізавета Антонівна Лопатка Олександр Юрійович Прасол Дарія Олександрівна Свириденко Діана Юріївна Сухарєва Вікторія Анатоліївна Фоменко Ілля Геннадійович Чумаченко Ярослав Дмитрович Шимко Карина Ашотівна Юрченко Вікторія Сергіївна popup.nrat_date 2020-04-02 Close