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Registration Number

0218U006890, 0116U008067 , R & D reports

Title

Nitrogen-containing fused systems of thiophene: the development of highly effective, environmentally friendly methods of synthesis and the search for anticancer drugs.

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Head

Shyyka Olga Yaroslavivna,

Registration Date

08-10-2018

Organization

Ivan Franko National University of Lviv

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Effective, chemoselective methods of synthesis of different classes of heterocyclic thieno-containing compounds based on 2- and 3-aminothiophenes accordingly to the criteria of "green chemistry" and allowing to construct complex molecular heterocyclic systems from simple accessible reagents by means of low-cost synthetic approaches were developed. In particular, a number of new derivatives of thieno [2,3-d] pyrimidines, triazolo [3,4-b] [1,3,4] thiadiazines, thieno [2,3-f] isoindoles, thieno [2,3-e ] [1,2,4] triazolo [1,5-c] pyrimidines, thieno [2,3-d] [1,2,4] triazolo [1,5-a] pyrimidines, thieno [3,2-d ] [1,2,3] triazinones were obtained. A new strategy for annulation of the pyrimidine cycle was developed using 1-substituted tetrazoles. The peculiarities of the domino-reaction of azides in the synthesis of new heterocyclic compounds were investigated. Aticancer activity evaluation was conducted in collaboration with the National Cancer Institute (USA) and it was found that some compounds posess a good antitumor activity.

Product Description

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Вахула Андрій Романович
Литвин Роман Зіновійович
Піткович Христина Євгенівна
Походило Назарій Тарасович
Тупис Андрій Миколайович

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2020-04-02